What medical indications are treated with Vortioxetine?

Vortioxetine (Atypical Anti-Depressant Drugs) is a pharmaceutical active substance. It is indicated for the treatment of Major Depressive Disorders.

What is the recommended dosage for Vortioxetine?

Standard adult dosage: Oral – Initially, 10 mg (once daily). Pediatric dosage: Not applicable. Always consult a registered physician for individualized dosage adjustments based on clinical assessment.

Is Vortioxetine safe during pregnancy and breastfeeding?

Vortioxetine is classified under Pregnancy Category "Not Assigned". Always consult your healthcare provider or OB/GYN before taking this medication during pregnancy or lactation.

What are the common side effects of Vortioxetine?

**More than 10%:**; Nausea (21-32%); **1-10%:**; Diarrhea (7-10%); Dizziness (6-9%); Dry mouth (6-8%); Constipation (3-6%); Vomiting (3-6%); Flatulence (1-3%); Pruritus (1-3%); Abnormal dreams (Less than 1-3%)

Dose.bd

Medicine Overview

Indication Guideline Dose Administration Side Effect Interaction Pregnancy Lactation Special Use Precaution Overdose Pharmacology Storage

Indication

Major Depressive Disorders

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Adult Dose

Clinical Information	Administration Information
Indication: Major depressive disorder Age: Adult	Dose: Oral – Initially, 10 mg Frequency: once daily Note: may be increased up to 20 mg once daily as tolerated or decreased to 5 mg once daily according to patient response. Efficacy and safety of doses greater than 20 mg/day have not been evaluated. Before initiating treatment screen for personal or family history of bipolar disorder, mania, or hypomania. Hepatic impairment: No dosage adjustment is necessary.
Indication: Major depressive disorder Age: Elderly	Dose: Oral – Initially, 5 mg Frequency: once daily Note: increased to 10 mg once daily if tolerated. Efficacy and safety of doses greater than 20 mg/day have not been evaluated. Before initiating treatment screen for personal or family history of bipolar disorder, mania, or hypomania. Hepatic impairment: No dosage adjustment is necessary.

Clinical Information

Administration Information

Indication: Major depressive disorder

Age: Adult

Dose: Oral – Initially, 10 mg

Frequency: once daily

Note: may be increased up to 20 mg once daily as tolerated or decreased to 5 mg once daily according to patient response. Efficacy and safety of doses greater than 20 mg/day have not been evaluated. Before initiating treatment screen for personal or family history of bipolar disorder, mania, or hypomania. Hepatic impairment: No dosage adjustment is necessary.

Indication: Major depressive disorder

Age: Elderly

Dose: Oral – Initially, 5 mg

Frequency: once daily

Note: increased to 10 mg once daily if tolerated. Efficacy and safety of doses greater than 20 mg/day have not been evaluated. Before initiating treatment screen for personal or family history of bipolar disorder, mania, or hypomania. Hepatic impairment: No dosage adjustment is necessary.

Child Dose

Clinical Information	Administration Information
Age: Pediatric	Dose: Not applicable Note: No approved pediatric dosage available

Renal Dose

Clinical Information	Administration Information
Condition: Renal impairment	Dose: Not specified Note: No dosage adjustment is necessary

Administration

Vortioxetine is administered orally as a film-coated tablet once daily, with or without food, at the same time each day. For adults under 65, the recommended starting dose is 10 mg, which may be adjusted between 5 mg and 20 mg based on tolerability; however, patients aged 65 and older should initiate therapy at 5 mg. No dosage adjustments are required for renal or hepatic impairment, but the maximum dose must not exceed 10 mg daily in known CYP2D6 poor metabolizers. To minimize withdrawal symptoms when discontinuing doses of 15 mg or 20 mg, the dosage should be reduced to 10 mg for one week prior to full cessation. Use is contraindicated within 14 days of stopping monoamine oxidase inhibitors (MAOIs) or 21 days before starting them.

Side Effect

More than 10%:

1-10%:

Drug Interaction

Details coming soon

Disease Interaction

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Pregnancy

US FDA Note

BNF Recommendation Note

AU TGA Note

Lactation

US FDA Note

BNF Recommendation Note

AU TGA Note

Special Use

Renal Impairment Note

Hepatic Impairment Note

Pediatric & Geriatric Use Note

Precaution

Precaution Note

Serotonin Syndrome

• Increased Risk of Bleeding

• Activation of Mania/Hypomania

• Angle Closure Glaucoma

• Hyponatremia

• Sexual Dysfunction

Overdose

Pharmacology

Mechanism of Action

Pharmacokinetics

Pharmacodynamics

Storage

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Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.