Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Malaria Prevention Age: Adult |
Dose: Tablet – 500 mg (300 mg base) Frequency: once weekly Note: by mouth |
|
Indication: Malaria Treatment Age: Adult Condition: Non-chloroquine-resistant |
Dose: Tablet – 1 g (600 mg base) Frequency: initial dose Note: by mouth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Malaria Prophylaxis |
Dose: by mouth (oral) – 5 mg/kg Frequency: once weekly |
|
Indication: Treatment Condition: 1st dose |
Dose: by mouth (oral) – 10 mg/kg Frequency: once |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified – Not specified Note: May need to reduce dose in prolonged treatment |
Administration
- Take with food
- Complete full course
Side Effect
- Retinopathy
- hair loss
- photosensitivity
- tinnitus
- myopathy (long-term therapy)
- Diarrhea
- Loss of appetite
- Nausea
- Stomach cramps
- Vomiting
- Psychosis
- seizures
- leucopenia and rarely aplastic anaemia
- hepatitis
- GI upsets
- dizziness
- hypokalaemia
- headache
- pruritus
- urticaria
- difficulty in visual accommodation
- Cardiac and respiratory arrest
- CV collapse
- convulsions
- coma
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Phenylbutazone
|
Predisposes to dermatitis
|
|
Neostigmine, Pyridostigmine
|
Antagonizes effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Known Or Suspected Resistant P. Falciparum Infection
|
Can lead to treatment failure
|
|
Porphyria
|
Can trigger acute attacks
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at room temperature in a dry place, away from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.