Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Schizophrenia, Psychotic Disorders Condition: Initially |
Dose: by mouth (oral) – 30-75 mg/day Frequency: divided every 6-12 hours Note: initially |
|
Indication: Schizophrenia, Psychotic Disorders Condition: Maintenance |
Dose: by mouth (oral) – 200 mg/day Note: up to 800 mg/day in some patients; some patients may require 1-2 g/day |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Behavioral Disorders, Hyperactivity Age: greater than 6 months |
Dose: Tablet/Injection – 50-100 mg Frequency: daily Note: by mouth (oral) or intramuscular; 200 mg/day or more may be necessary for older hospitalized patients |
|
Indication: Behavioral Disorders, Hyperactivity Age: greater than 6 months Condition: outpatient |
Dose: Rectal – 0.55 mg/kg Frequency: every 4-6 hours as needed |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Severe renal impairment |
Dose: Small doses Note: Start with small doses in severe renal impairment because of increased cerebral sensitivity. |
Administration
- Take with food
- Take at regular times
Side Effect
- Extrapyramidal symptoms
- Tardive dyskinesia (on long-term therapy)
- Involuntary movements of extremities may also occur
- Dry mouth
- constipation
- urinary retention
- mydriasis
- agitation
- insomnia
- depression and convulsions
- postural hypotension
- ECG changes
- Allergic skin reaction
- amenorrhoea
- gynaecomastia
- weight gain
- Hyperglycaemia and raised serum cholesterol
- Agranulocytosis
- Instantaneous deaths associated with ventricular tachyarrhythmias
- Marked elevation of body temperature with heat stroke
- Neuroleptic malignant syndrome
- extrapyramidal dysfunction
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Antiparkinson agents, TCAs
|
Potentiation of anticholinergic effects
|
|
MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide)
|
Additive orthostatic hypotensive effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Comatose States
|
Can worsen CNS depression
|
|
Large Amounts Of CNS Depressants
|
Risk of severe sedation
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.