Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: by mouth – 25-100 mg/day Frequency: once daily Note: usual range, 12.5-25 mg/day |
|
Indication: Edema Age: Adult |
Dose: by mouth – 50-100 mg/day Frequency: once daily Note: not to exceed 200 mg/day |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Creatinine Clearance less than 10 mL/min |
Dose: Not specified Note: Ineffective; do not use |
|
Condition: Creatinine Clearance greater than 10 mL/min |
Dose: Not specified Note: Dose adjustment not necessary |
Administration
- Take with food
- Take in the morning
Side Effect
- Cardiovascular Hypotension
- vasculitis
- Dermatologic Photosensitivity
- phototoxicity
- Endocrine/metabolic Electrolyte abnormalities
- hyperglycemia
- hyperuricemia
- Gastrointestinal Constipation
- diarrhea
- loss of appetite
- nausea
- vomiting
- Musculoskeletal Spasticity
- Neurologic Dizziness
- headache
- paresthesia
- Ophthalmologic Blurred vision
- xanthopsia
- Psychiatric Restlessness
- Reproductive Impotence
- Rare
- Severe hyponatraemia and idiosyncratic hypersensitivity
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
|
Antagonize hypotensive action
|
|
Oral Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban)
|
Suppresses action due to reduced prothrombin activity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Renal Impairment
|
Can worsen kidney function
|
|
Anuria
|
Can cause electrolyte imbalance
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool & dry place, away from children
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.