Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult |
Dose: Tablet by mouth – 25 mg Frequency: once daily at bedtime Note: Recommended Dose. The decision of dose increase has to be balanced with a higher risk of transaminases elevation. |
|
Age: Adult |
Dose: Tablet by mouth – 25-50 mg Frequency: at bedtime Note: Any dose increase to 50 mg should be made on an individual patient benefit/risk basis and with strict respect of liver function test (LFT) monitoring. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Not applicable – Not applicable Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment with severe impairment |
Dose: Not specified Note: No relevant modification in agomelatine pharmacokinetic parameters observed; |
|
Condition: Moderate to severe impairment |
Dose: Not specified Note: Caution in moderate to severe impairment. |
Administration
- Take at bedtime
- Can be taken with or without food
Side Effect
- Dizziness
- somnolence
- insomnia
- migraine
- headache
- nausea
- diarrhoea
- constipation
- upper abdominal pain
- hyperhidrosis
- back pain
- tiredness
- anxiety
- elevated liver enzymes
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
|
Increased or decreased bioavailability
|
|
Oestrogens
|
May affect bioavailability
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hepatic Impairment
|
Risk of liver damage
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place away from light. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.