Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Lennox-Gastaut syndrome (LGS) Age: 2 years or older |
Dose: by mouth – Initiate at 5 mg Frequency: every 12 hours Note: May titrate as tolerated up to 40 mg/day divided every 12 hours. Dose escalation should not proceed more rapidly than once weekly. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Lennox-Gastaut syndrome Age: 2 years or older |
Dose: Oral – 5 mg Frequency: once daily Note: Starting dose; titrate as tolerated up to 20 mg by mouth daily; after 7 days, may increase to 5 mg by mouth twice daily; if needed, may increase to 10 mg by mouth twice daily after an additional 7 days |
|
Indication: Lennox-Gastaut syndrome Age: 2 years or older |
Dose: Oral – 5 mg Frequency: twice daily Note: Starting dose; titrate as tolerated up to 40 mg by mouth daily; after 7 days, may increase to 10 mg by mouth twice daily; if needed, may increase to 20 mg by mouth twice daily after an additional 7 days |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild or moderate renal impairment |
Dose: No dose adjustment required Note: No dose adjustment required |
|
Condition: Severe renal impairment or end stage renal disease |
Dose: No experience Note: Severe renal impairment or end stage renal disease: No experience |
Administration
- Can be taken with or without food
- Take at regular intervals
Side Effect
- Somnolence or sedation (26%)
- Somnolence (22%)
- Pyrexia (13%)
- Upper respiratory tract infection (URTI) (12%)
- Drooling (9%)
- Aggression (8%)
- Irritability (7%)
- Vomiting (7%)
- Insomnia (5%)
- Ataxia (5%)
- Sedation (5%)
- Constipation (5%)
- Fatigue (5%)
- Cough (5%)
- Psychomotor hyperactivity (4%)
- Pneumonia (4%)
- Urinary Tract Infection (UTI) (4%)
- Dysarthria (3%)
- Decreased appetite (3%)
- Increased appetite (3%)
- Bronchitis (2%)
- Dysphagia (2%)
- Respiratory depression
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Phenytoin, Phenobarbital, Carbamazepine
|
Increased hepatic clearance of clobazam
|
|
Cimetidine
|
May increase levels of clobazam
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
History Of Drug Dependence
|
Risk of addiction
|
|
Myasthaenia Gravis
|
Can worsen muscle weakness
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not use the medicine later than the date of expiry. Store below 30° and protect from light. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.