Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Adjunct for cataplexy associated with narcolepsy Age: Adult |
Dose: Oral – Initially, 10 mg Frequency: once daily Note: Dose gradually increased to 10-75 mg daily. |
|
Indication: Adjunct for cataplexy associated with narcolepsy Age: Elderly |
Dose: Oral – Dose reduction may be needed Note: Specific dosage not provided for this age group. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Obsessive-Compulsive Disorder Age: less than 10 years |
Dose: Oral – Not established Note: Safety and efficacy not established |
|
Indication: Obsessive-Compulsive Disorder Age: greater than 10 years |
Dose: Oral – 25 mg Frequency: once daily Note: initially; by mouth (oral) |
Administration
- Take with food
- Take at same time daily
Side Effect
- Xerostomia (84%)
- Headache (50-55%)
- Constipation (47%)
- Ejaculation failure (42%)
- Fatigue (35-40%)
- Nausea (30-35%)
- Impotence (20-25%)
- Weight gain (18%)
- Weight loss (5%)
- Hepatotoxicity (1-3%)
- Common
- Dizziness
- mainia
- somnolence
- tremor
- Dyspepsia
- Blurred vision
- Urinary retention
- Orgasm incapacity
- libido change
- Death
- rare (except in patients with preexisting significant heart block and patients on MAOI therapy)
- Induction of mania in individuals with underlying manic-depressive illness or worsening of psychoses in already psychotic individuals
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Barbiturates
|
Increase metabolism of tricyclic antidepressants
|
|
Cimetidine, Guanethidine, Haloperidol, Phenothiazines
|
Block the tricyclic metabolism
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Concomitant Use Of MAOIs
|
Risk of serotonin syndrome
|
|
Recovery Phase Following MI
|
Can affect heart recovery
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep out of the reach and sight of children. The capsules should be protected from heat and moisture.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.