Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Immediate-release tablets – 0.1 mg Frequency: 12 hourly Note: Range: 0.1-0.2 mg/day 12 hourly; increased every 2nd or 3rd day according to response. Maximum: 2.4 mg daily |
|
Indication: Hypertension Age: Adult |
Dose: Extended-release tablets – 0.1 mg Frequency: once daily at bedtime Note: Dosage may be increased in increments of 0.1 mg per day at weekly intervals. The maximum recommended dosage is 0.4 mg once daily at bedtime |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: less than 12 years old |
Dose: Safety and efficacy not established Note: Safety and efficacy not established |
|
Indication: Hypertension Age: greater than 12 years old |
Dose: Immediate-release tablets – 0.2 mg/day Frequency: divided 12 hourly Note: increase once weekly; Maintenance dose range, 0.2-0.6 mg/day 12 hourly; not to exceed 2.4 mg/day; by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Not assessed – Initial dose adjustment should be based on amount of renal impairment Note: Monitor carefully for hypotension and bradycardia; Removed minimally during hemodialysis; no need to redose following dialysis |
Administration
- Can be taken with or without food
- Monitor blood pressure
Side Effect
- Skin reactions
- patch (15-50%)
- Dry mouth (40%)
- Somnolence (19-38%)
- Headache (19-29%)
- Fatigue (13-24%)
- Drowsiness (33%)
- Dizziness (13-16%)
- Hypotension
- epidural (45%)
- Postural hypotension
- epidural (32%)
- Anxiety (11%)
- Constipation (10%)
- Sedation (10%)
- Nausea/vomiting
- PO (5%)
- Malaise (3%)
- Orthostatic hypotension (3%)
- Anorexia
- PO (1%)
- Abnormal LFTs (1%)
- Rash (1%)
- Weight gain
- PO (1%)
- Upper respiratory tract infection (URTI)
- Irritability
- Throat pain
- Nightmares
- Insomnia
- Emotional disorder
- Constipation
- Nasal congestion
- Transient hypertension or profound hypotension
- respiratory depression
- convulsion
- Clonidine withdrawal syndrome could be life threatening
- Bradycardia
- coma and disturbances in conduction (in individuals with preexisting diseases of SA/AV nodes
- overdose or on digitalis)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene), Vasodilators
|
Hypotensive action may be potentiated
|
|
TCAs, Centrally-acting alpha-blockers
|
Effects of clonidine antagonized
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Disorders Of Cardiac Pacemaker Activity And Conduction
|
Can cause dangerous heart rhythm problems
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25°C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.