Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Transfusional Iron Overload Age: Adult Condition: Thalassemia syndromes when current chelation therapy is inadequate |
Dose: PO – 25 mg/kg Frequency: three times daily Note: Maximum dose: 100 mg/kg/day. Round the dose to the nearest 250 mg. Approval based on serum ferritin level reduction; no controlled trials demonstrating a direct treatment benefit (e.g., improvement in disease-related symptoms, functioning, or increased survival). |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Transfusional Iron Overload Age: greater than 3 years Condition: caused by thalassemia syndromes, sickle cell disease, or other anemias |
Dose: Tablet – 25 mg/kg Frequency: three times daily Note: by mouth (oral). Initial dose. Approval based on serum ferritin level reduction; no controlled trials demonstrating a direct treatment benefit (e.g., improvement in disease-related symptoms, functioning, or increased survival). Maximum dose: 100 mg/kg/day. Round the dose to the nearest 250 mg. 500-mg tablet (aged greater than 8 years). |
|
Indication: Transfusional Iron Overload Age: less than 3 years |
Dose: Not specified Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: #REF! |
-
|
Administration
- Can be taken with or without food
- Take at regular intervals
Side Effect
- Chromaturia (14.6%)
- Nausea (12.6%)
- Abdominal pain/discomfort (10.4%)
- Arthralgia (9.8%)
- Vomiting (9.8%)
- Increased ALT (7.5%)
- Decreased neutrophil count (7.3%)
- Neutropenia (6.2%)
- Increased appetite (4%)
- Diarrhea (3%)
- Headache (2.5%)
- Dyspepsia (2%)
- Back pain (2%)
- Extremity pain (1.9%)
- Increased weight (1.9%)
- Agranulocytosis (1.7%)
- Arthropathy (1.4%)
- Increased AST (1.2%)
- Decreased appetite (1.1%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Aluminium-containing antacids
|
Can chelate trivalent metal ions, avoid using together
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Agranulocytosis
|
Can cause severe blood disorder
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 30° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.