Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Supraventricular and ventricular arrhythmias Age: Adult |
Dose: Conventional capsules – 300-800 mg daily Frequency: in divided doses every 6 hours Note: Adjusted according to patient's response. |
|
Indication: Supraventricular and ventricular arrhythmias Condition: Hepatic impairment |
Dose: Oral – 400 mg daily Frequency: in divided doses |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Ventricular Arrhythmias Age: less than 1 year old |
Dose: Oral – 10-30 mg/kg/day Frequency: divided every 6 hours Note: by mouth (oral) |
|
Indication: Ventricular Arrhythmias Age: 1-4 years old |
Dose: Oral – 10-20 mg/kg/day Frequency: divided every 6 hours Note: by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance greater than 40 ml/min |
Dose: 400 mg Frequency: daily in divided doses |
|
Condition: Renal impairment: Creatinine Clearance 30-40 ml/min |
Dose: 100 mg Frequency: every 8 hours Note: avoid modified release preparations |
Administration
- Take with or without food
- Take at evenly spaced intervals
Side Effect
- Xerostomia (32%)
- Urinary hesitancy (23%)
- Constipation (11%)
- Impotence
- Urinary urgency
- Urinary retention
- Dry throat
- Weight gain
- Abdominal distension
- Flatulence
- Anorexia
- Vomiting
- Nausea
- Dermatoses
- Pruritus
- Generalized rash
- Increased triglycerides and cholesterol
- Hypokalemia
- Muscle weakness
- Muscular pain
- Dyspnea
- Blurred vision
- Dry eyes
- Fatigue
- Malaise
- Headache
- Dizziness
- Nervousness
- Syncope
- Hypotension
- Chest pain
- Edema
- AV block
- Hypoglycemia (rare)
- Agranulocytosis
- Respiratory distress
- Creatinine increased
- Psychotic reaction
- Paresthesia
- Lupus (rare)
- Peripheral neuropathy
- Insomnia
- Urinary retention
- severe cardiovascular depression if given as rapid IV inj
- High risk of recurrence of failure in patients with history of congestive cardiac failure
- Negative inotropic effect especially prominent in patients with cardiomyopathy
- hypertension and uncompensated cardiac failure
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Class I Antiarrhythmics (Amiodarone, Flecainide, Propafenone, Quinidine, Disopyramide, Procainamide), Other cardiac depressants including Beta-blockers (Propranolol, Metoprolol, Atenolol, Bisoprolol, Carvedilol, Nadolol, Timolol, Sotalol)
|
Avoid except in life-threatening arrhythmias
|
|
Other anti-arrhythmics
|
Risk of worsening arrhythmias, precipitation of new arrhythmias and ventricular fibrillation
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Complete Heart Block
|
Can worsen conduction
|
|
Glaucoma
|
Can increase eye pressure
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.