Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Mild to moderately severe dementia in Alzheimer's disease Age: Adult |
Dose: Oral – 5 mg Frequency: once daily at bedtime Duration: 4-6 weeks Note: Initially, 5 mg daily at bedtime, increase if necessary up to 10 mg once daily at bedtime after 4-6 weeks. |
|
Indication: Mild to moderately severe dementia in Alzheimer's disease Age: Adult |
Dose: Oral – 10 mg Frequency: once daily at bedtime Note: Increase if necessary up to 10 mg once daily at bedtime after 4-6 weeks of 5 mg daily dose. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Form – No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Tablet – 5 mg or 10 mg Note: A similar dose schedule can be followed for patients with renal impairment as clearance of donepezil hydrochloride is not affected by these conditions |
Administration
- Take with or without food
- Take in the evening
Side Effect
- Nausea
- vomiting
- anorexia
- weight loss
- diarrhoea
- insomnia
- fatigue
- muscle cramps
- headache and dizziness
- syncope
- bradycardia
- convulsions
- increased liver transaminases
- sinoatrial and atrioventricular block
- hallucinations
- agitation and aggressive behavior
- minor increases in plasma creatine kinase
- potentially bladder outflow obstruction
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Antipsychotics (Haloperidol, Risperidone, Quetiapine, Olanzapine, Clozapine, Aripiprazole)
|
May increase the neurotoxic effect
|
|
Systemic Corticosteroids (Prednisone, Prednisolone, Methylprednisolone, Dexamethasone, Hydrocortisone)
|
May increase adverse effects of donepezil
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Not available
|
Not available
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.