Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: HIV infection Age: Adult Condition: Combined with other antiretrovirals |
Dose: Oral – 600 mg Frequency: once daily Note: Dosing at bedtime recommended during 1st 2-4 weeks of therapy to improve tolerability. |
|
Indication: HIV infection Age: Adult Condition: Mild (Child-Pugh Class A) hepatic impairment |
Dose: Oral – 600 mg Frequency: once daily Note: Dose adjustment not necessary; use caution. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: HIV infection Age: greater than 3 years Condition: Combined with other antiretrovirals |
Dose: Oral – 200 mg Frequency: once daily |
|
Indication: HIV infection Age: greater than 3 years Condition: Combined with other antiretrovirals |
Dose: Oral – 250 mg Frequency: once daily |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Renal impairment – No dosage adjustment needed Note: Renal impairment: No dosage adjustment needed |
Administration
- Take on empty stomach
- Take at bedtime
Side Effect
- Total cholesterol increased (20-40%)
- Diarrhea (3-14%
- children up to 39%)
- HDL increased (25-35%)
- Dizziness (28.1%)
- Rash (5-26%)
- Fever (children 21%)
- Depression (19%)
- Insomnia (16.3%)
- Cough (children 16%)
- Vomiting (3-12%)
- Anxiety (2-13%)
- Nausea (2-12%)
- Neutropenia (2-10%)
- Pruitis (9%)
- Impaired concentration (8.3%)
- Transaminases increased (2-8%)
- Somnolence (7.0%)
- Abnormal dreams (6.2%)
- Amylase increased (6%)
- Hyperglycemia (2-5%)
- Dyspepsia (4%)
- Abdominal pain (2-3%)
- Anorexia (2%)
- Hallucinations (1.2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Hormonal contraceptives
|
Interaction
|
|
Rifampicin, Rifabutin, Clarithromycin
|
Interaction with antibacterials
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Hepatic Impairment
|
Can worsen liver function
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 25°C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.