Medicine Overview

Indication

Know Medicine, Follow Guideline

Adult Dose

Clinical InformationAdministration Information
Indication: Deep Vein Thrombosis Prophylaxis
Condition: Abdominal surgery
Dose: Subcutaneous Injection – 40 mg
Frequency: once daily
Duration: 7 to 10 days; up to 12 days has been administered in clinical trials or until risk of deep vein thrombosis has diminished
Note: Initiate 2 hours preoperatively.
Indication: Deep Vein Thrombosis Prophylaxis
Condition: Knee or hip replacement surgery
Dose: Subcutaneous Injection – 30 mg
Frequency: every 12 hours
Duration: 7 to 10 days; up to 14 days has been administered in clinical trials or until risk of deep vein thrombosis has been significantly reduced or patient is on anticoagulant therapy; initiate therapy 12 to 24 hours postoperatively and continued for 10 days or up to 35 days postoperatively
Note: Duration of administration is 7 to 10 days; up to 14 days has been administered in clinical trials or until risk of DVT has diminished.

Child Dose

Clinical InformationAdministration Information
Age: Child
Dose: Form – No approved pediatric dosage available
Note: No approved pediatric dosage available

Renal Dose

Clinical InformationAdministration Information
Indication: Prophylaxis in abdominal surgery
Condition: Severe renal impairment (Creatinine Clearance less than 30 mL/minute)
Dose: Subcutaneous Injection – 30 mg
Frequency: once daily
Note: Dosage reductions required
Indication: Prophylaxis in hip or knee replacement surgery
Condition: Severe renal impairment (Creatinine Clearance less than 30 mL/minute)
Dose: Subcutaneous Injection – 30 mg
Frequency: once daily
Note: Dosage reductions required
Administration
  • Given by subcutaneous injection
  • Inject into fatty tissue of abdomen
Side Effect

Drug Interaction

Drug NameRisk Factors
Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban), Platelet aggregation inhibitors (e.g. dipyridamole, salicylates, NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), sulfinpyrazone)
Increased risk of bleeding
Vitamin E
May increase bleeding

Disease Interaction

Disease NameRisk Factors
Major Clotting Disorders like History of Thrombocytopenia
Increased bleeding risk
Active Gastro-Intestinal Ulcer
Risk of severe bleeding

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protect from light and moisture. Do not store above 25°C. Do not store in a refrigerator or freezer. Keep out of the reach of children

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.