Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Adjunct to levodopa treatment in Parkinson's disease Age: Adult |
Dose: Oral – 200 mg Frequency: with each levodopa/dopa decarboxylase inhibitor dose Note: Maximum: 200 mg 10 times daily (2,000 mg daily). |
|
Condition: Hepatic Impairment |
Dose: Oral Note: Safety and efficacy not established |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Renal Dose Note: Dosage adjustment not necessary |
Administration
- Take with or without food
- Take with each levodopa dose
Side Effect
- Dyskinesia (25%)
- Nausea (14%)
- Diarrhea (10%)
- Hyperkinesia (10%)
- Urine discoloration (10%)
- Hypokinesia (9%)
- Dizziness (8%)
- Abdominal pain (8%)
- Fatigue (6%)
- Constipation (6%)
- Back pain (4%)
- Vomiting (4%)
- Dry mouth (3%)
- Dyspnea (3%)
- Increased sweating (2%)
- Back pain (2%)
- Anxiety (2%)
- Somnolence (2%)
- Dyspepsia (2%)
- Flatulence (2%)
- Purpura (2%)
- Asthenia (2%)
- Hallucinations (1-4%)
- Taste perversion (1%)
- Agitation (1%)
- Gastritis (1%)
- Bacterial infection (1%)
- Insomnia
- Postural hypotension
- Confusion
- Dopaminergic side affects due to increased dopamine levels
- Rare rhabdomyolysis
- retroperitoneal fibrosis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Adrenaline, Apomorphine, Dobutamine, Dopamine, Isoprenaline, Methyldopa, Noradrenaline, Remiterol
|
May affect metabolism
|
|
Iron preparations, Levodopa
|
Interaction
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
History of Neuroleptic Malignant Syndrome
|
Risk of recurrence
|
|
History of Nontraumatic Rhabdomyolysis
|
Risk of muscle breakdown
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 25°C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.