Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: New patients |
Dose: Tablet – 4-FDC (Rifampicin 150 mg + Isoniazid 75 mg + Pyrazinamide 400 mg + Ethambutol 275 mg) 2 tablets Frequency: once daily Duration: Initial 2 months |
|
Indication: New patients |
Dose: Tablet – 2-FDC (Rifampicin 600 mg + Isoniazid 300 mg) 2 tablets Frequency: once daily Duration: next 4 months Note: continuation dose |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Intensive phase of treating tuberculosis Age: Children |
Dose: Tablet – 2 tablets Frequency: Once daily Note: Route: Oral; Maximum Dose: 5 tablets daily |
|
Indication: Intensive phase of treating tuberculosis Age: Children |
Dose: Tablet – 2 tablets Frequency: Once daily Note: Route: Oral; Maximum Dose: 5 tablets daily |
Administration
- Take on empty stomach
- Take 1 hour before or 2 hours after meals
Side Effect
- Rifampicin Reddish discolouration of body fluids
- asymptomatic increase in liver enzymes
- elevations of BUN & uric acid
- hemolysis
- hematuria
- intestinal nephritis
- renal insufficiency
- GI discomfort
- CNS effects
- hematological changes
- skin rash
- endocrine effects
- INH Disturbances of liver function
- hepatitis
- GI disturbances
- peripheral neuropathy
- dizziness
- lightheadedness
- hematological changes
- allergic reactions
- Pyrazinamide Transient rise in serum transaminases
- hepatotoxicity
- hepatomegaly
- jaundice
- hyperuricemia
- intestinal nephritis
- dysuria
- GI disturbances
- hematological changes
- allergic reactions
- Ethambutol Confusion
- disorientation
- headache
- visual disturbances
- jaundice
- transient liver dysfunction
- GI disturbances
- hematological changes
- allergic effects
- acute gout (rare)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Methadone, Oral Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban), Glucocorticoids, Oestrogen, Oral hypoglycaemic agents, Digitoxin, Antiarrhythmics (Amiodarone, Flecainide, Propafenone, Quinidine, Disopyramide, Procainamide), Theophylline, Anticonvulsants (Phenytoin, Carbamazepine, Valproic acid, Lamotrigine, Levetiracetam, Topiramate), β-blockers, Azole antifungal, Cyclosporin
|
Accelerates clearance (Rifampicin)
|
|
Antiepileptics, Benzodiazepines (Diazepam, Alprazolam, Lorazepam, Clonazepam, Midazolam), Warfarin, Theophylline
|
Inhibits metabolism (INH)
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
History of Drug-Induced Hepatitis
|
Risk of liver damage
|
|
Acute Liver Disease
|
Can worsen liver function
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at temperatures not exceeding 30°C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.