Medicine Overview

Indication

Know Medicine, Follow Guideline

Adult Dose

Clinical InformationAdministration Information
Indication: Hyperlipidaemias; Homozygous familial sitosterolaemia
Age: Adult
Dose: Oral – 10 mg
Frequency: once daily
Note: Hepatic impairment: Mild (Child-Pugh class A): Dose adjustment not necessary
Indication: Hyperlipidaemias; Homozygous familial sitosterolaemia
Age: Adult
Condition: Moderate to severe hepatic impairment (Child-Pugh class B or C)
Dose: Oral – Not recommended
Note: Moderate to severe hepatic impairment (Child-Pugh class B or C): Not recommended

Child Dose

Clinical InformationAdministration Information
Age: greater than 10 years
Dose: Tablet – 10 mg
Frequency: once daily

Renal Dose

Clinical InformationAdministration Information
Age: Adult
Condition: Renal impairment monotherapy
Dose: Not specified
Note: No dosage adjustment required
Age: Adult
Condition: Moderate to severe renal impairment
Dose: Not specified
Note: Renal impairment is a risk factor for statin-associated myopathy; caution when coadministered with doses of simvastatin exceeding 20 mg
Administration
  • Take with or without food
  • Take once daily
Side Effect

Drug Interaction

Drug NameRisk Factors
Colestyramine
Reduced absorption
Ciclosporin
Increased plasma concentrations

Disease Interaction

Disease NameRisk Factors
Moderate to Severe Liver Disease
Can worsen liver function
Unexplained Serum Transaminase Elevation
Risk of liver damage

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool & dry place protected from light and moisture. Keep out of reach of children.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.