Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hyperlipidaemias; Homozygous familial sitosterolaemia Age: Adult |
Dose: Oral – 10 mg Frequency: once daily Note: Hepatic impairment: Mild (Child-Pugh class A): Dose adjustment not necessary |
|
Indication: Hyperlipidaemias; Homozygous familial sitosterolaemia Age: Adult Condition: Moderate to severe hepatic impairment (Child-Pugh class B or C) |
Dose: Oral – Not recommended Note: Moderate to severe hepatic impairment (Child-Pugh class B or C): Not recommended |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: greater than 10 years |
Dose: Tablet – 10 mg Frequency: once daily |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult Condition: Renal impairment monotherapy |
Dose: Not specified Note: No dosage adjustment required |
|
Age: Adult Condition: Moderate to severe renal impairment |
Dose: Not specified Note: Renal impairment is a risk factor for statin-associated myopathy; caution when coadministered with doses of simvastatin exceeding 20 mg |
Administration
- Take with or without food
- Take once daily
Side Effect
- Diarrhea (4%)
- Upper respiratory tract symptoms (2-4%)
- Cough (2-4%)
- Pain in extremity (3%)
- Sinusitis (3%)
- Arthralgia (2-3%)
- Fatigue (2%)
- Influenza (2%)
- Increased liver transaminases (with HMG-CoA reductase inhibitors, More than 3 x ULN
- 1%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Colestyramine
|
Reduced absorption
|
|
Ciclosporin
|
Increased plasma concentrations
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Moderate to Severe Liver Disease
|
Can worsen liver function
|
|
Unexplained Serum Transaminase Elevation
|
Risk of liver damage
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool & dry place protected from light and moisture. Keep out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.