Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Replacement therapy in adrenocortical insufficiency Age: Adult |
Dose: Oral – 20-30 mg Frequency: twice daily |
|
Indication: Supplement in adrenal insufficiency during minor surgery under general anaesthesia Age: Adult Condition: In patients taking greater than 10 mg of prednisolone or its equivalent by mouth daily |
Dose: Intravenous – 25-50 mg Note: At induction. Resume with usual oral corticosteroid after surgery. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Replacement therapy in adrenocortical insufficiency Age: Child |
Dose: Oral – 400-800 mcg/kg/day Frequency: in 2-3 divided doses |
|
Indication: Acute adrenocortical insufficiency Age: Child Condition: less than 1 year |
Dose: Intravenous – 25 mg Note: Fluids and electrolytes should be administered as needed to correct any metabolic disorder. Doses may also be given via intramuscular injection but the response may be slower. |
Administration
- Take with food
- Regular timing
Side Effect
- Sodium and fluid retention
- Potassium and calcium depletion
- Muscle wasting
- weakness
- osteoporosis
- GI disturbances and bleeding
- Increased appetite and delayed wound healing
- Bruising
- striae
- hirsutism
- acne
- flushing
- Raised intracranial pressure
- headache
- depression
- psychosis
- menstrual irregularities
- Hyperglycaemia
- glycosuria
- DM
- obesity
- moon-face
- buffalo hump
- Suppression of pituitary-adrenocortical system
- Growth retardation in childn (prolonged therapy)
- Increased susceptibility for infection
- Topical use Dermal atrophy
- local irritation
- folliculitis
- hypertrichosis
- Inhaled corticosteroids May cause hoarseness
- candidiasis of mouth and throat
- Topical application to the eye Can produce Corneal ulcer
- raised IOP and reduced visual function
- Intralesional injection Local hypopigmentation of deeply pigmented skin
- Intra-articular injection Joint damage
- fibrosis esp in load bearing joints
- Abrupt withdrawal leading to acute adrenal insufficiency
- Rapid IV Injection may cause CV collapse
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Thiazides
|
May enhance hyperglycaemia and hypokalaemia caused by corticosteroids
|
|
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
|
Increased incidence of peptic ulcer or GI bleeding
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Viral/Fungal Infections
|
Can worsen infections
|
|
Tubercular Or Syphilitic Lesions
|
Can mask while worsening condition
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.