Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic bronchospasm Age: Adult |
Dose: Oral – 225-450 mg Frequency: twice daily Note: As hydrate: Initially, increased if necessary. |
|
Indication: Reversible airway obstruction Age: Adult |
Dose: Oral Modified-release Medicines – 225 mg Frequency: twice daily Duration: 1 week Note: Initially, adjusted according to plasma theophylline concentration. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic bronchospasm Age: Child: greater than 3 years |
Dose: Oral – As modified-release hydrate: 12 mg/kg Frequency: daily Note: increased to 24 mg/kg daily in 2 divided doses after 1 week |
|
Indication: Chronic asthma Age: Child |
Dose: Oral – Initially 225 mg Frequency: twice daily Duration: for 1 week Note: by mouth using modified-release medicines, then increased if necessary to 450 mg twice daily, adjusted according to plasma theophylline concentration |
Administration
- Take with food
- Take at same times daily
Side Effect
- Nausea
- vomiting
- abdominal pain
- diarrhoea
- headache
- insomnia
- dizziness
- anxiety
- restlessness
- tremor
- palpitations
- Convulsions
- cardiac arrhythmias
- hypotension and sudden death after too rapid IV injection
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Other xanthines
|
Interaction noted
|
|
Allopurinol, Some Antiarrhythmics (Amiodarone, Flecainide, Propafenone, Quinidine, Disopyramide, Procainamide), Cimetidine, Disulfiram, Fluvoxamine, Interferon-alpha, Macrolide Antibiotics (Erythromycin, Clarithromycin, Azithromycin), Quinolones, Oral contraceptives, Thiabendazole, Viloxazine
|
Clearance reduced
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 20 to 25°C
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.