Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Psychoses Age: Adult |
Dose: Oral – 0.5-5 mg Frequency: twice daily or three times daily Note: may increase up to 100 mg daily in severe or resistant cases. Usual maintenance: 3-10 mg daily. |
|
Indication: Tourette's syndrome; Severe tics Age: Adult |
Dose: Oral – 0.5-1.5 mg Frequency: three times daily Note: Up to 30 mg daily may be required in Tourette's syndrome; adjust dose carefully to obtain optimum response; usual maintenance: 4 mg daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 3 years |
Dose: Safety and efficacy not established Note: Safety and efficacy not established |
|
Indication: Psychosis/Sedation Age: 3-12 years |
Dose: Oral – 0.25-0.5 mg/day Frequency: divided every 8-12 hours Note: initially; may be increased by 0.5 mg/day every 5-7 days as needed; by mouth (oral) |
Administration
- Can take with/without food
- Regular timing
Side Effect
- Akathisia
- Dystonia
- Muscle stiffness
- Neuroleptic malignant syndrome (NMS, infrequent but serious)
- Parkinsonism
- Tardive dyskinesia
- Anticholinergic effects
- Sedation
- Weight gain
- Erectile dysfunction
- Oligomenorrhea or amenorrhea
- Orthostatic hypotension (after IM injection)
- tachycardia Agitation
- anxiety
- cerebral edema
- depression
- dizziness
- euphoria
- headache
- insomnia
- poikilothermia
- restlessness
- weakness
- confusion
- Anorexia
- constipation
- dyspepsia
- ileus
- decreased gag reflex
- Lens opacities (prolonged use)
- ECG changes
- Photosensitivity
- Pruritus
- Diarrhea
- Blood dyscrasia
- Ejaculatory disorder
- Galactorrhea
- Rare Seizure
- Cholestatic jaundice
- Priapism
- Neuroleptic malignant syndrome
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Carbamazepine, Rifampicin
|
Reduce plasma concentrations
|
|
Alcohol, Hypnotics, General anaesthetics, Anxiolytics, Opioids
|
Enhanced symptoms of CNS depression
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Toxic CNS Depression
|
Can worsen CNS depression
|
|
Preexisting Coma
|
Can deepen coma
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep away from light and out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.