Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Ventricular Arrhythmias |
Dose: Oral – 800-1600 mg Frequency: once daily Duration: 1-3 weeks Note: continue until response; once adequate arrhythmia control is achieved, reduce dose to 600-800 mg/day for 1 month; THEN reduce to the maintenance dose |
|
Indication: Ventricular Arrhythmias Condition: Oral Maintenance |
Dose: Oral – 400 mg Frequency: once daily |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Tablet – No approved pediatric dosage available Note: No approved pediatric dosage available |
Administration
- Take with or without food
- Take consistently
Side Effect
- Increased liver AST or ALT levels (3-20%, as high as 40-50% in some studies)
- Hypotension (16%)
- Dizziness (3-40%)
- Headache (3-40%)
- Malaise (3-40%)
- Abnormal gait/ataxia (3-40%)
- Fatigue (3-40%)
- Impaired memory (3-40%)
- Involuntary movement (3-40%)
- Sleep disturbances (3-40%)
- Photosensitivity (10-75%)
- Hypothyroidism (1-22%)
- Constipation (10-33%)
- Anorexia (10-33%)
- CHF (3%)
- Bradycardia (3-5%)
- AV block (5%)
- SA node dysfunction (1-3%)
- Hyperthyroidism (3-10%)
- Hepatitis and cirrhosis (Less than 3%)
- Visual disturbances (2-9%)
- Optic neuritis (1%)
- Corneal microdeposits
- Demyelinating polyneuropathy
- Pulmonary toxicity including pulmonary fibrosis and interstitial pneumonitis
- hepatotoxicity
- thyrotoxicity
- Ventricular arrhythmias
- pulmonary alveolitis
- exacerbation of arrhythmias and rare serious liver injury
- Generally in patients with high doses and having preexisting abnormalities of diffusion capacity
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Other antiarrhythmic drugs
|
Potentiation
|
|
Anaesthetic agents
|
Possible increased risk of adverse effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Sinus Node Dysfunction
|
Can cause dangerous heart rhythm
|
|
2nd and 3rd Degree Heart Block
|
Dangerous without pacemaker
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 20° to 25°C. Protect from light and excessive heat. Use carton or blister pack to protect contents from light until used.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.