Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Germ cell testicular carcinoma Age: Adult |
Dose: Intravenous – 1.2 g/m2/day Frequency: once daily Duration: for 5 days Note: via slow infusion over at least 30 minutes, repeat treatment every 3 weeks or after recovery from haematological toxicity. To be given with mesna and adequate hydration of at least 2 L of oral or intravenous fluid per day. |
|
Indication: Lymphoma; Sarcoma; Solid tumours Age: Adult Condition: Regimen 1 |
Dose: Intravenous – 8-12 g/m2 Duration: divided over 3-5 days Note: repeat course every 2-4 weeks. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance (ml/min) less than 10 |
Dose: Administer 75% of dose Note: Renal impairment: Creatinine Clearance (ml/min) less than 10 Administer 75% of dose. |
Administration
- Hospital use only
- Given by IV
Side Effect
- Alopecia (83%)
- Nausea (58%)
- Vomiting (58%)
- Leukopenia (50%)
- Hematuria (46%)
- Metabolic acidosis (31%)
- Thrombocytopenia (20%)
- CNS toxicity (12%)
- Neurotoxicity (10-20%)
- Infection (8%)
- Nephrotoxicity (6%)
- Severe myelosuppression
- haemorrhagic cystitis
- nephrotoxicity
- cardiotoxicity
- coma
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Allopurinol, Cisplatin
|
Enhanced toxicity
|
|
Warfarin
|
Enhances the anticoagulant effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Bone-Marrow Depression
|
Can dangerously reduce blood cells
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 20-25° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.