Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Tuberculosis Age: Adult |
Dose: Tablet – 3 tablets of 150 mg rifampicin / 100 mg isoniazid Frequency: once daily Note: Each tablet contains rifampicin and isoniazid (mg) |
|
Indication: Tuberculosis Age: Adult |
Dose: Tablet – 2 tablets of 300 mg rifampicin / 150 mg isoniazid Frequency: once daily Note: Each tablet contains rifampicin and isoniazid (mg) |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Tuberculosis Age: Children younger than 15 years |
Dose: Oral – Use and dose must be determined by your doctor Note: Maximum Dose: Isoniazid 300 mg, Rifampin 600 mg |
Administration
- Take on empty stomach
- Regular timing
Side Effect
- Unwanted effects which may occur during continuous daily or intermittent therapy Rifampicin Rifampicin may cause reddish discolouration of body fluids and occasionally other body secretions eg urine
- sputum
- lacrimal fluid
- faeces
- saliva and sweat
- It may permanently discolour soft contact lenses
- an asymptomatic increase in liver enzymes
- severe life-threatening hepatic reactions eg hepatic failure and acute fulminant hepatitis are uncommon (More than 0.1% andLess than 1%)
- In isolated cases (Less than 0.01%)
- a fatal outcome was observed
- Renal Effects Elevations of BUN and serum uric acid
- haemolysis
- haematuria
- interstitial nephritis
- renal insufficiency
- Gastrointestinal Effects Nausea
- abdominal pains
- vomiting or diarrhoea
- pseudomembranous colitis
- Central and Peripheral Nervous System Effects Tiredness
- drowsiness
- headache
- dizziness
- ataxia
- mental confusion
- muscular weakness
- visual disturbances
- Haematological Changes Leucopenia
- eosinophilia
- thrombocytopenia and thrombocytopenic purpura
- Effects on Skin and Appendages Flushing
- itching with or without skin rash
- urticaria
- reddening of the eyes
- exudative conjunctivitis or generalised hypersensitivity reactions involving the skin eg exfoliative dermatitis
- Lyell's syndrome and pemphigoid reactions
- Endocrine Effects Disturbances in the menstrual cycle
- induction of crisis in Addison patients
- Unwanted effects chiefly occurring during intermittent therapy or upon resumption of treatment after temporary interruption
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Hormonal contraceptives
|
May reduce effectivity
|
|
Antacids
|
Reduced absorption
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Drug-induced hepatitis
|
Risk of recurrent liver damage
|
|
Acute liver diseases
|
Can cause severe liver toxicity
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.