Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: HIV infection Age: Adult |
Dose: Oral – 150 mg Frequency: twice daily Note: In combination with other antiretrovirals. |
|
Indication: HIV infection Age: Adult |
Dose: Oral – 300 mg Frequency: once daily Note: In combination with other antiretrovirals. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: HIV infection Age: 3 months to 12 years |
Dose: Oral – 4 mg/kg Frequency: twice daily Note: Maximum: 300 mg/day |
|
Indication: Chronic hepatitis B Age: greater than 2 years |
Dose: Oral – 3 mg/kg Frequency: once daily Note: Maximum: 100 mg/day |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: HIV infection Condition: Renal impairment (Creatinine Clearance 30-49 ml/min) |
Dose: Oral – 1st dose 150 mg, then 150 mg Frequency: once daily Note: Dialysis patients: Not recommended. |
|
Indication: HIV infection Condition: Renal impairment (Creatinine Clearance 15-29 ml/min) |
Dose: Oral – 1st dose 150 mg, then 100 mg Frequency: once daily Note: Dialysis patients: Not recommended. |
Administration
- Can take with/without food
- Regular timing
Side Effect
- Cough
- Diarrhea
- Fatigue & malaise
- Fever (peds)
- Headache
- Musculoskeletal pain
- Nausea
- Nervous system neuropathy
- Pancreatitis
- Peripheral neuropathy
- Nasal S/S
- Vomiting
- Abdominal cramps
- abdominal pain
- Anorexia &/or decrease appetite
- Arthralgia
- Chills
- Depression
- Dizziness
- Dyspepsia
- Insomnia
- Myalgia
- Rash
- Thrombocytopenia
- Creatine phosphokinase increased
- Body fat redistribution
- Elevated amylase
- Neutropenia
- Hepatitis B exacerbation
- Lactic acidosis associated with severe hepatomegaly and hepatic steatosis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Trimethoprim (Co-trimoxazole)
|
Renal excretion may be inhibited
|
|
Zalcitabine
|
May antagonise the antiviral action
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe liver disease
|
Risk of lactic acidosis
|
|
Severe kidney disease
|
Risk of drug accumulation
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.