Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral – Initially, 10 mg Frequency: once daily Note: First dose given preferably at bedtime to avoid precipitous fall in blood pressure. Maintenance: 20 mg once daily, up to 80 mg/day may be given if needed. |
|
Indication: Hypertension Age: Adult Condition: Renovascular hypertension, volume depletion, or severe hypertension |
Dose: Oral – Initially, 2.5-5 mg Frequency: once daily |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Pediatric greater than 6 years |
Dose: Oral – 0.07 mg/kg Frequency: once daily Note: up to 5 mg once daily. Initially, 0.07 mg/kg. |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult Condition: Renal impairment: Creatinine Clearance less than 10 mL/min or on dialysis |
Dose: Tablet – 2.5 mg Frequency: once daily Note: Initially. Dose can be adjusted up to maximum 40 mg once daily based on patient's response. |
|
Indication: Hypertension Age: Adult Condition: Renal impairment: Creatinine Clearance 10-30 mL/min |
Dose: Tablet – 2.5-5 mg Frequency: once daily Note: Initially. Dose can be adjusted up to maximum 40 mg once daily based on patient's response. |
Administration
- Can take with/without food
- Regular timing
Side Effect
- Dizziness (5-12%)
- Cough (4-9%)
- Headache (4-6%)
- Hyperkalemia (2-5%)
- Diarrhea (3-4%)
- Hypotension (1-4%)
- Chest pain (3%)
- Fatigue (3%)
- Nausea/vomiting (2%)
- Kidney disease of AMI patients (2%)
- Rash (1-2%)
- Immune hypersensitivity reaction
- Psoriasis
- Angioedema of the face
- lips
- throat
- intestinal angioedema
- Anuria
- Atrial tachycardia
- Acute renal failure
- Arthralgia
- Alopecia
- Atrial fibrillation
- Bone marrow suppression
- Cutaneous pseudolymphoma
- Hypersomnia
- Leukopenia
- Mood changes
- Pancreatitis
- Skin infections
- Severe hypotension
- angioedema
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene)
|
May enhance hypotensive effect
|
|
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
|
May increase risk of renal function deterioration and decrease antihypertensive effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
History of angioedema with ACE inhibitors
|
Risk of recurrent angioedema
|
|
Hereditary angioedema
|
Can trigger severe swelling
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at below 25° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.