Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Oliguric phase of renal failure Age: Adult |
Dose: Intravenous infusion – 50-100 g Duration: in a 24-hour period Note: Adjust rate of administration to maintain a urine flow of at least 30-50 mL/hr. |
|
Indication: Cerebral oedema, Reduction of raised intraocular pressure Age: Adult |
Dose: Intravenous infusion – 0.25-2 g/kg Duration: given over 30-60 minutes |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Edema Condition: Intravenous |
Dose: Intravenous – 0.25-1 g/kg Note: initially |
|
Indication: Edema Condition: Intravenous |
Dose: Intravenous – 0.25-0.5 g/kg Frequency: every 4-6 hours Note: maintenance dose |
Administration
- Hospital use only
- Given by IV
Side Effect
- Fluid and electrolyte imbalance
- acidosis (with high doses)
- Nausea
- vomiting
- thirst
- headache
- dizziness
- convulsions
- chills
- fever
- tachycardia
- chest pain
- blurred vision
- urticaria and hypotension or hypertension
- acute renal failure
- skin necrosis
- thrombophloebitis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Ciclosporin
|
Increased nephrotoxicity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Pulmonary congestion
|
Risk of fluid overload
|
|
Pulmonary edema
|
Can worsen breathing
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Mannitol should be stored at a temperature of 20° to 30°. Exposure to lower temperatures may cause deposition of crystals, which should be dissolved by warming the bottle in hot water for about 30 minutes. Cool to body temperature before using. If all crystals can not be dissolved, the solution should not be used. The content of open containers should be used promptly. Unused contents should be discarded.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.