Medicine Overview

Indication
Know Medicine, Follow Guideline

Adult Dose
Clinical InformationAdministration Information
Indication: Systemic fungal infections (Aspergillus species, Candida species, and/or Cryptococcus species infections)
Age: Adult
Condition: Liposomal amphotericin B
Dose: Intravenous – Test dose 1 mg infused over 10 minutes, then 3 mg/kg
Frequency: once daily
Duration: At least 14 days
Note: Infusion over 30-60 minutes. Maximum: 5 mg/kg daily.
Indication: Cryptococcal Meningitis
Age: Adult
Condition: HIV-infected patients
Dose: Intravenous – 6 mg/kg
Frequency: every day

Child Dose
Clinical InformationAdministration Information
Indication: Systemic Fungal Infections
Condition: Test dose
Dose: Intravenous – 0.1 mg/kg
Note: not to exceed 1 mg; administer over 20-60 minutes
Indication: Systemic Fungal Infections
Condition: Initial dose
Dose: Intravenous – 0.25 mg/kg/dose
Frequency: once daily or every other day

Renal Dose
Clinical InformationAdministration Information
Condition: Renal Impairment, Creatinine Clearance less than 10 mL/minute
Dose: Intravenous – 0.5-0.7 mg/kg
Frequency: every 24-48 hours
Note: Consider other antifungal agents that may be less nephrotoxic
Condition: Intermittent hemodialysis
Dose: Intravenous – 0.5-1 mg/kg
Frequency: once daily after dialysis session
Administration
  • Hospital use only
  • Given by IV infusion
Side Effect

Drug Interaction
Drug NameRisk Factors
Flucytosine
Increased toxicity
Nephrotoxic medications
Enhanced drug induced renal toxicity

Disease Interaction
Disease NameRisk Factors
No specific contraindications listed
Monitor for general reactions

Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Unopened vials of lyophilized material are to be stored at temperatures up to 25°C. The reconstituted product concentrate may be stored for up to 24 hours at 2-8° C.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.