Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 2 Diabetes Age: Adult |
Dose: Oral Tablet – 2 mg/500 mg Frequency: once or twice daily Note: Recommended starting dose. May titrate by increments of 500 mg/2 mg at 2-week intervals, not to exceed 2000 mg/8 mg per day. |
|
Indication: Type 2 Diabetes Age: Adult Condition: HbA1c greater than 11% or fasting plasma glucose (FPG) greater than 270 mg/dL |
Dose: Oral Tablet – 500 mg/2 mg Frequency: twice daily Note: Starting dose may be considered. May titrate by increments of 500 mg/2 mg at 2-week intervals, not to exceed 2000 mg/8 mg per day. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Metformin Note: Contraindicated |
|
Condition: Renal impairment |
Dose: Metformin Note: Not recommended to initiate treatment |
Administration
- Take with meals
- Take at regular intervals
Side Effect
- Edema (6% to 25% )
- Upper respiratory infections (16-20%)
- Diarrhea (12.7% to 14%)
- Hypoglycemia (12% )
- Anemia (4% to 7%)
- Fatigue (6%)
- Headache (6%)
- Sinusitis (6%)
- Arthralgia (5%)
- Back pain (5%)
- Viral infection (5%)
- Angioedema (rare)
- Congestive heart failure
- Death
- from cardiovascular causes
- Stevens-Johnson syndrome (rare)
- Lactic acidosis (rare)
- Hepatotoxicity (rare)
- Anaphylaxis (rare)
- Diabetic macular edema
- Pleural effusion
- Pulmonary edema
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Same as Metformin Hydrochloride
|
Same effects as Metformin Hydrochloride
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Renal Disease (Serum Creatinine >5 mg/dL Males)
|
Impairs drug clearance
|
|
Renal Disease (Serum Creatinine >4 mg/dL Females)
|
Impairs drug clearance
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool dry place protected from light. Keep out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.