Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Fibromyalgia Age: Adult |
Dose: Oral – 12.5 mg Frequency: once daily Duration: Day 1 |
|
Indication: Fibromyalgia Age: Adult |
Dose: Oral – 25 mg/day (12.5 mg twice daily) Frequency: twice daily Duration: Days 2-3 |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 17 years |
Dose: Not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild renal impairment (Creatinine Clearance 50-80 mL/min) |
Dose: Dosage Form – No dosage adjustment required Note: No dosage adjustment required |
|
Condition: Moderate renal impairment (Creatinine Clearance 30-49 mL/min) |
Dose: Dosage Form – Use with caution Note: Use with caution |
Administration
- Take with food
- Take at same times each day
Side Effect
- Nausea (37%)
- Headache (18%)
- Constipation (16%)
- Hot flush (12%)
- Insomnia (12%)
- (selected) Dizziness
- Hyperhidrosis
- Hypertension
- Migraine
- Palpitations
- Tachycardia
- Vomiting
- Xerostomia
- Abnormal bleeding
- Depression (worsening)
- Serotonin syndrome
- Suicidal thoughts
- Withdrawal signs or symptoms
- Serotonin syndrome or neuroleptic malignant syndrome (NMS)-like reactions
- suicidal thinking/behaviour
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Aspirin, NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), Warfarin, Other drugs that affect coagulation
|
Increased risk of bleeding
|
|
Clomipramine
|
Increased CNS effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Uncontrolled Narrow-Angle Glaucoma
|
Can increase eye pressure
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 25° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.