Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Oral Depression Age: Adult |
Dose: Oral – 75-100 mg/day Frequency: in 3 or 4 divided doses Note: Maximum: 150 mg/day in severe depression. |
|
Indication: Oral Depression Age: Elderly |
Dose: Oral – 30-50 mg/day Frequency: in divided doses |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Depression Age: Adolescent |
Dose: Oral – 30-50 mg/day Frequency: in divided doses |
|
Indication: Nocturnal enuresis Age: Child: 6-7 yr |
Dose: Oral – 10 mg Frequency: 30 minutes before bedtime Duration: not greater than 3 months |
Administration
- May be taken with or without food
- Take at bedtime unless directed otherwise
Side Effect
- Hypotension
- HTN
- tachycardia
- palpitation
- MI
- arrhythmias
- heart block
- stroke
- confusional states w/ hallucinations
- disorientation
- delusions
- anxiety
- restlessness
- agitation
- insomnia
- panic
- nightmares
- hypomania
- exacerbation of psychosis
- suicidal ideation and behaviours
- numbness
- tingling
- paraesthesia
- incoordination
- ataxia
- tremors
- peripheral neuropathy
- extrapyramidal symptoms
- seizures
- tinnitus
- dry mouth
- blurred vision
- accommodation disturbances
- mydriasis
- constipation
- paralytic ileus
- urinary retention
- delayed micturition
- dilation of the urinary tract
- Rash
- itching
- urticaria
- photosensitisation
- oedema (general or of face and tongue)
- bone-marrow depression including agranulocytosis
- aplastic anaemia
- eosinophilia
- thrombocytopenia
- Nausea
- vomiting
- anorexia
- epigastric distress
- diarrhoea
- peculiar taste
- stomatitis
- abdominal cramps
- malaise
- jaundice
- hepatitis and liver necrosis
- Sweating
- flushing
- urinary frequency
- nocturia
- drowsiness
- dizziness
- weakness
- fatigue
- headache
- parotid swelling
- alopecia
- Gynaecomastia
- breast enlargement and galactorrhoea
- increased or decreased libido
- impotence
- testicular swelling
- elevation or reduction of blood sugar levels
- inappropriate secretion of antidiuretic hormone syndrome
- weight gain or loss
- altered liver function
- Rarely
- associated sublingual adenitis or gingivitis
- Rare
- blood dyscrasias
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
SSRIs, SNRIs, TCAs, Triptans, Fentanyl, Lithium, Tramadol, Tryptophan, Buspirone
|
Increased risk of serotonin syndrome
|
|
Bethanidine, Guanethidine, Debrisoquine, Clonidine
|
May reduce antihypertensive effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Mania
|
Can trigger manic episodes
|
|
Recent MI
|
Risk of cardiac complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 15-30° C. Protect from light and moisture.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.