Medicine Overview

Indication
Know Medicine, Follow Guideline

Adult Dose
Clinical InformationAdministration Information
Indication: Hypertension
Age: Adult
Dose: Oral – Initial: 10-20 mg
Frequency: once daily
Note: may then be increased up to maximum 40 mg once daily if needed.
Indication: Hypertension
Age: Elderly
Dose: Oral – No dosage adjustment needed
Frequency: Not mentioned

Child Dose
Clinical InformationAdministration Information
Indication: Hypertension
Age: 6-16 years
Dose: Oral – 10 mg
Frequency: once daily
Note: dosage range: 10-20 mg/day
Indication: Hypertension
Age: 6-16 years
Dose: Oral – 20 mg
Frequency: once daily
Note: Doses may be doubled once if necessary after 2 weeks; dosage range: 20-40 mg/day

Renal Dose
Clinical InformationAdministration Information
Condition: Renal impairment: Mild to moderate (Creatinine Clearance: 20-60 mL/minute)
Dose: Not specified – 20 mg
Frequency: once daily
Note: Maximum: 20 mg once daily
Administration
  • Take at same time each day
  • May take with or without food
Side Effect

Drug Interaction
Drug NameRisk Factors
ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril), Potassium-sparing diuretics (Amiloride, Eplerenone, Spironolactone, Triamterene), K salts, K supplements
Increased risk of hyperkalaemia
Antihypertensive (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, Propranolol, Metoprolol, Atenolol, Carvedilol, Bisoprolol, Nadolol, Amlodipine, Diltiazem, Verapamil, Nifedipine, Nicardipine, Hydrochlorothiazide, Chlorthalidone, Indapamide, Furosemide, Bumetanide, Torsemide, Spironolactone, Amiloride, Triamterene, Prazosin, Doxazosin, Terazosin, Clonidine, Methyldopa, Hydralazine, Minoxidil)
May potentiate BP lowering effects

Disease Interaction
Disease NameRisk Factors
Biliary Obstruction
Drug metabolism affected

Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in cool & dry place below 30ºC, protect from light & moisture. Keep out of the reach of children.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.