Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Anxiety Condition: Mild to moderate |
Dose: Oral – 10-15 mg Frequency: 3-4 times daily |
|
Indication: Anxiety Condition: Severe, agitation or associated with depression |
Dose: Oral – 15-30 mg Frequency: 3-4 times daily |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Anxiety Age: greater than 12 years Condition: Mild to moderate |
Dose: Oral – 10-15 mg Frequency: 3-4 times daily |
|
Indication: Anxiety Age: greater than 12 years Condition: Severe, agitation or associated with depression |
Dose: Oral – 15-30 mg Frequency: 3-4 times daily |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: No dosage adjustment needed |
Administration
- May be taken with or without food
- Take at bedtime for sleep
Side Effect
- Sleep and visual disturbances
- drowsiness
- dizziness
- vertigo
- lethargy
- headache
- tremor
- ataxia
- mild paradoxical reactions (eg excitement, stimulation of affect)
- minor diffuse skin rashes (eg morbilliform, maculopapular and urticarial)
- nausea
- oedema
- slurred speech
- altered libido
- GI symptoms
- Rarely
- transient anterograde amnesia or memory impairment
- syncope
- leucopenia and hepatic dysfunction including jaundice
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Barbiturates, Antipsychotics (Haloperidol, Risperidone, Quetiapine, Olanzapine, Clozapine, Aripiprazole), Sedatives/hypnotics, Anxiolytics, Antidepressants (Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Venlafaxine, Duloxetine), Sedative Antihistamines (Diphenhydramine, Loratadine, Levocetirizine, Cetirizine, Fexofenadine, Hydroxyzine, Bilastin), Anticonvulsants (Phenytoin, Carbamazepine, Valproic acid, Lamotrigine, Levetiracetam, Topiramate), Anaesthetics
|
Additive CNS depressant effects
|
|
Narcotic analgesics
|
Increased psychic dependence
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Acute Alcohol Intoxication
|
Risk of respiratory depression
|
|
Myasthenia Gravis
|
Can worsen muscle weakness
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light and moisture. Keep out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.