Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: General Anesthesia Adjunct/Cesarean Section Condition: Loading Dose |
Dose: Intravenous – 0.04-0.1 mg/kg Note: Dose should be calculated based on ideal body weight. Monitoring of muscle twitch response to a peripheral nerve stimulator is advised. |
|
Indication: General Anesthesia Adjunct/Cesarean Section Condition: Maintenance |
Dose: Intravenous – 0.015-0.1 mg/kg Frequency: every 30-60 minutes Note: Dose should be calculated based on ideal body weight. Monitoring of muscle twitch response to a peripheral nerve stimulator is advised. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Neonates (less than 28 Days Old) Condition: Loading dose |
Dose: Intravenous – 0.02 mg/kg Note: Intravenous |
|
Age: Neonates (less than 28 Days Old) Condition: Maintenance dose |
Dose: Intravenous – 0.05-0.1 mg/kg Frequency: every 0.5-4 hours as needed Note: Intravenous |
Administration
- For IV use only
- Must be given by anesthesiologist
Side Effect
- Tachycardia may occur due to vagal blockade and especially during light anaesthesia
- May decrease intra-ocular pressure and induce miosis
- excessive salivation
- transient rashes and itching
- wheezing
- elevation in pulse rate
- BP
- cardiac output
- erythema
- burning sensation along vein
- profound muscle weakness
- bronchospasm
- hypersensitivity reaction
- acute quadriplegic myopathy syndrome
- myositis ossificans
- Rare anaphylactoid reactions
- bradycardia
- bronchospasm
- hypotension and CV collapse
- respiratory depression
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Neuroleptanalgaesia
|
May decrease neuromuscular activity
|
|
Aminoglycoside Antibiotics (Gentamicin, Amikacin, Tobramycin, Neomycin, Streptomycin, Paromomycin), Lithium, Diazepam, Lidocaine, Quinidine, Tetracyclines, Propranolol, Thiamine, Parenteral magnesium sulphate, MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide), Quinine, Protamine, Carbamazepine, Donepezil, Phenytoin
|
Action may be prolonged and/or potentiated
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Anuria
|
Drug clearance affected
|
|
Reduced Airway Control
|
Risk of respiratory failure
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.