Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Conventional tablet or Oral solution – 40-80 mg Frequency: twice daily Note: Usual range: 160-320 mg/day. Maximum: 640 mg/day. |
|
Indication: Hypertension Age: Adult |
Dose: Extended release capsule – 80 mg Frequency: once daily Note: Usual range: 120-160 mg once daily. Maximum: 640 mg/day. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Child |
Dose: Conventional tablet – Initially, 1 mg/kg/day Frequency: in 2 divided doses Note: Usual range: 2-4 mg/kg/day in 2 divided doses. Max: 4 mg/kg/day in 2 or 3 divided doses. |
|
Indication: Phaeochromocytoma Age: Child |
Dose: Conventional tablet or oral solution – 0.25-0.5 mg/kg Frequency: 3-4 times daily |
Administration
- Tablet: Take before meals
- Capsule: Can be taken with or without food
Side Effect
- Most adverse effects have been mild and transient and have rarely required the withdrawal of therapy
- Cardiovascular Bradycardia
- congestive heart failure
- intensification of AV block
- hypotension
- paresthesia of hands
- thrombocytopenic purpura
- arterial insufficiency
- usually of the Raynaud type
- Central Nervous System Lightheadedness
- mental depression manifested by insomnia
- lassitude
- weakness
- fatigue
- reversible mental depression progressing to catatonia
- visual disturbances
- hallucinations
- vivid dreams
- an acute reversible syndrome characterized by disorientation for time and place
- short-term memory loss
- emotional lability
- slightly clouded sensorium
- and decreased performance on neuropsychometrics
- For immediate formulations
- fatigue
- lethargy
- and vivid dreams appear dose related
- Gastrointestinal Nausea
- vomiting
- epigastric distress
- abdominal cramping
- diarrhea
- constipation
- mesenteric arterial thrombosis
- and ischemic colitis
- Allergic Hypersensitivity reactions
- including anaphylactic/anaphylactoid reactions
- pharyngitis and agranulocytosis
- erythematous rash
- fever combined with aching and sore throat
- laryngospasm
- and respiratory distress
- Respiratory Bronchospasm
- Hematologic Agranulocytosis
- nonthrombocytopenic purpura
- and thrombocytopenic purpura
- Skin Stevens-Johnson Syndrome
- toxic epidermal necrolysis
- exfoliative dermatitis
- erythema multiforme
- and urticaria
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Amiodarone, Disopyramide, Quinidine, Flecainide, Calcium Channel Blockers (Amlodipine, Diltiazem, Verapamil, Nifedipine, Felodipine, Nicardipine, Isradipine)
|
May cause additive negative chronotropic and/or inotropic effect
|
|
Phenothiazines
|
May cause additive hypotensive effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Sinus Bradycardia
|
Dangerously slows heart rate
|
|
Bronchial Asthma
|
Can trigger severe attacks
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.