Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Oral Tuberculosis Age: Adult Condition: Standard unsupervised 2-month treatment |
Dose: Oral – 1.5 g Frequency: once daily Duration: 2 months Note: As part of a multidrug regimen. Hepatic impairment: Severe: Contraindicated. |
|
Indication: Oral Tuberculosis Age: Adult Condition: Standard unsupervised 2-month treatment |
Dose: Oral – 2 g Frequency: once daily Duration: 2 months Note: As part of a multidrug regimen. Hepatic impairment: Severe: Contraindicated. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Tuberculosis Age: Child Condition: As part of a multidrug regimen for standard unsupervised 2-month treatment |
Dose: Oral – 35 mg/kg Frequency: daily |
|
Indication: Tuberculosis Age: Child Condition: As part of a multidrug regimen for intermittent supervised 2-month treatment |
Dose: Oral – 50 mg/kg Frequency: 3 times weekly |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: dose reduction Note: May need dose reduction |
Administration
- Take with food
- Complete full course of treatment
Side Effect
- Malaise
- Nausea
- Vomiting
- Anorexia
- Arthralgia
- Myalgia
- Fever
- Rash
- Itching
- Acne
- Photosensitivity
- Gout
- Dysuria
- Porphyria
- Thrombocytopenia
- Hepatotoxicity
- Interstitial nephritis
- Severe liver damage
- fulminant hepatitis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Uricosuric Agents (Probenecid, Sulfinpyrazone) (e.g. probenecid, sulfinpyrazone)
|
Antagonises effect
|
|
Oestrogens
|
May reduce contraceptive effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Existing Liver Disease
|
Can worsen liver damage
|
|
Acute Gout
|
Can trigger gout attacks
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-30° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.