Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute migraine attacks Age: Adult |
Dose: Oral – Initially 10 mg Frequency: as needed Note: If ineffective, second dose should not be taken for the same attack. If symptoms recur after initial response, a further dose of 10 mg may be given. Doses should be separated by at least 2 hours. Maximum: 20 mg/24 hours. |
|
Indication: Acute migraine attacks Age: Adult Condition: Patient is also taking propanolol |
Dose: Oral – 5 mg Frequency: as needed Note: Maximum: 10 mg/24 hours. Ensure that the 2 drugs are separated by at least 2 hours. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute treatment of migraine with or without aura Age: less than 6 years |
Dose: Oral – Note: Safety and efficacy not established |
|
Indication: Acute treatment of migraine with or without aura Age: 6-17 years |
Dose: Oral – 5 mg Frequency: once every 24 hours Note: by mouth (oral). Efficacy and safety of treatment with more than 1 dose within 24 hours in pediatric patients has not been established. If taking propranolol: Do not administer rizatriptan. |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild-moderate renal impairment |
Dose: Form – 5 mg Frequency: Initial dose; further dose of 5 mg may be taken after an interval of at least 2 hours Note: Maximum 10 mg/24 hours |
|
Condition: Severe renal impairment |
Dose: Form – Not specified Note: Avoid use in severe impairment |
Administration
- Can be taken with or without food
- Take at onset of migraine
Side Effect
- Drowsiness (13-30%
- dose related)
- Fatigue (13-30%
- dose related)
- Dizziness (11-15%)
- Dizziness (4-9%)
- Somnolence (4-8%)
- Fatigue (4-7%
- dose related)
- Nausea (4-6%)
- Asthenia (1-5%)
- Hot flashes (1-5%)
- Paresthesia (3-4%)
- Dry mouth (3%)
- Chest pain (2-3%)
- Pain/pressure in chest
- neck
- throat
- jaw (Less than 2%)
- Headache (Less than 2%)
- Dyspnea (More than 1%)
- Hypoesthesia (More than 1%)
- Palpations (More than 1%)
- Skin flushing (More than 1%)
- Tachycardia
- Angioedema
- Wheezing
- Hypertensive crisis
- Bradycardia
- Hallucination
- Epidermal necrolysis
- Hearing impairment
- Arrhythmias
- Myocardial infarction and coronary artery vasospasm in patients with CAD risk factors
- Toxic epidermal necrolysis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Propranolol
|
Increased serum concentrations
|
|
Ergotamine, Methysergide
|
Increased risk of vasospastic reactions
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
History of MI
|
Risk of heart attack
|
|
Peripheral Vascular Disease
|
Can worsen circulation
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 15-30° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.