Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Tuberculosis Age: Adult |
Dose: Intramuscular – 15 mg/kg Frequency: once daily Note: Maximum: 1 g daily. |
|
Indication: Tuberculosis Age: Adult Condition: As part of intermittent regimen |
Dose: Intramuscular – 25-30 mg/kg Frequency: 2-3 times weekly Note: Maximum: 1.5 g/dose. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Moderate to Severe Infections Age: Child |
Dose: Intramuscular – 20–30 mg/kg/day Frequency: every 12 hours Note: maximum 1 g/day |
|
Indication: Tuberculosis Age: Child |
Dose: Intramuscular – 20-40 mg/kg Frequency: once daily Note: as a single dose daily; Maximum: 1 g daily |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Intramuscular – 1 g Note: Loading dose |
|
Condition: Renal Impairment |
Dose: Intramuscular – 7.5 mg/kg Frequency: every 24 hours Note: For Creatinine Clearance: 50-80 mL/min |
Administration
- Must be administered by healthcare professional
- For injection use only
Side Effect
- Neurotoxic reactions (eg vestibular and cochlear function disturbance
- optic nerve dysfunction
- peripheral neuritis
- arachnoiditis
- encephalopathy)
- paraesthesia of face
- rash
- fever
- angioneurotic oedema
- eosinophilia
- exfoliative dermatitis
- azotemia
- leucopenia
- thrombocytopenia
- pancytopenia
- haemolytic anaemia
- muscular weakness
- amblyopia
- Resp paralysis from neuromuscular blockade
- Clostridium difficile-associated diarrhoea
- anaphylaxis
- rarely
- nephrotoxicity
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
H1-receptor blockers
|
May mask early signs of ototoxicity
|
|
Zalcitabine
|
May reduce excretion
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-30°C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.