Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Gastrointestinal Stromal Tumor Condition: after disease progression on or intolerance to imatinib mesylate |
Dose: Tablet – 50 mg Frequency: once daily Duration: 4 weeks, then 2 weeks drug-free, repeat cycle Note: Continue until disease progression or unacceptable toxicity |
|
Indication: Advanced Renal Cell Carcinoma |
Dose: Tablet – 50 mg Frequency: once daily Duration: 4 weeks, then 2 weeks drug-free, repeat cycle Note: Continue until disease progression or unacceptable toxicity |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established Note: Safety and efficacy not established in pediatric patients |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Renal Dose Note: No dose adjustment necessary |
Administration
- Can be taken with or without food
- Take at same time daily
Side Effect
- Dyspepsia (MRCC 46%)
- Altered taste (MRCC 43%, GIST 21%)
- Fatigue (GIST 42%, MRCC 74%)
- Diarrhea (GIST 40%, MRCC 55%)
- Rash (MRCC 38%, GIST 14%)
- Vomiting (MRCC 37%, GIST 24%)
- Constipation (MRCC 34%, GIST 20%)
- Skin discoloration (MRCC 33%, GIST 30%)
- Abdominal pain (GIST 33%, MRCC 20%)
- Nausea (GIST 31%, MRCC 54%)
- Anorexia (MRCC 31%, GIST 33%)
- Mucositis/stomatitis (GIST 29%, MRCC 53%)
- Dyspnea (MRCC 28%, GIST 10%)
- HTN (MRCC 28%, GIST 15%)
- Arthralgia (MRCC 28%, GIST 12%)
- Bleeding (MRCC 26%, GIST 18%)
- Headache (MRCC 25%, GIST 13%)
- Asthenia (GIST 22%)
- Lymphopenia (MRCC 21%)
- Fever (GIST 18%, MRCC 15%)
- Limb pain (MRCC 18%)
- Back pain (MRCC 17%, GIST 11%)
- Myalgia (MRCC 17%, GIST 14%)
- Cough (MRCC 17%, GIST 8%)
- Dry skin (17%)
- Hair color changes (17%)
- Neutropenia (MRCC 13%, GIST 11%)
- Alopecia (MRCC 12%)
- Hand-foot syndrome (MRCC 12%, GIST 14%)
- Dehydration (MRCC 11%)
- Venous thrombotic events
- Hemorrhoids
- Pancreatitis
- Flu-like syndrome
- Hepatotoxicity
- Acute renal failure
- Adrenal dysfunction
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Ketoconazole, Ritonavir, Itraconazole, Erythromycin, Clarithromycin, Grapefruit juice
|
Increased plasma concentration
|
|
Rifampin, Dexamethasone, Phenytoin, Carbamazepine, Phenobarbital, St. John's wort
|
Decreased plasma concentration
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity
|
Risk of severe allergic reactions
|
|
Renal Impairment
|
Risk of drug toxicity
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.