Medicine Overview

Indication

Know Medicine, Follow Guideline

Adult Dose

Clinical InformationAdministration Information
Indication: Hypertension
Age: Adult
Dose: Oral Tablet – 8 mg
Frequency: once daily
Note: Initially 8 mg once daily, increased if necessary up to 32 mg once daily, doses to be increased at intervals of 4 weeks. Maintenance: 8 mg once daily. Maximum: 32 mg per day as single or in 2 divided doses.
Indication: Hypertension
Age: Adult
Condition: Intravascular volume depletion
Dose: Oral Tablet – 4 mg
Frequency: once daily
Note: Initially 4 mg once daily, increased if necessary up to 32 mg daily, doses to be increased at intervals of 4 weeks; usual dose 8 mg once daily.

Child Dose

Clinical InformationAdministration Information
Indication: Hypertension
Age: 1 to less than 6 years
Dose: Oral – Initially, 200 mcg/kg/day
Note: May increase according to response to 50-400 mcg/kg/day; All doses may be given as single or in 2 divided doses
Indication: Hypertension
Age: 6 to less than 17 years
Dose: Oral – 4-8 mg/day
Note: Adjusted according to response to 2-16 mg/day; All doses may be given as single or in 2 divided doses

Renal Dose

Clinical InformationAdministration Information
Condition: Mild renal impairment
Dose: Form – Not specified
Note: No dose adjustment necessary for patients with mild renal impairment
Condition: Moderate renal impairment
Dose: Form – Not specified
Note: Initiate therapy at lower dose if moderate renal impairment
Administration
  • Can be taken with or without food
  • Take at same time each day
Side Effect

Drug Interaction

Drug NameRisk Factors
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
May reduce antihypertensive effect and deteriorate renal function
Lithium
May increase serum concentration

Disease Interaction

Disease NameRisk Factors
No specific contraindications listed
Monitor for general drug reactions

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool & dry place. Protect from light and moisture

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.