Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acromegaly Age: Adult Condition: Initial therapy |
Dose: Solution – 50 mcg Frequency: every 8 hours Note: Subcutaneous; titrate up to 500 mcg every 8 hours if necessary |
|
Indication: Acromegaly Age: Adult Condition: Maintenance after 2 weeks successful solution treatment |
Dose: Suspension (depot injection) – 20 mg Frequency: every 4 weeks Duration: 3 months Note: Intramuscular (gluteal); titrate up or down to 10-30 mg every 4 weeks depending on response; not to exceed 40 mg |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Tablet – Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment without dialysis |
Dose: Not specified – Dose adjustment not necessary Note: Dose adjustment not necessary |
|
Condition: Renal impairment with dialysis |
Dose: Intramuscular – 10 mg Frequency: Every 4 weeks Note: Initial dose, then titrate to effect |
Administration
- For IV push: Inject slowly over 3 minutes
- For infusion: Give over 15-30 minutes
Side Effect
- Gallbladder problems (More than 60%) Decreased gallbladder contractility
- gallstones
- cholecystitis
- cholestatic hepatitis
- Dysglycemia (25%)
- Hypothyroidism (25%)
- Bradycardia (25%)
- ECG changes (10%)
- Arrhythmia (9%)
- Pancreatitis
- Upper respiratory tract infection (URTI)
- Fatigue
- Headache
- Malaise
- Rash
- Diarrhea
- Nausea
- Vomiting
- Pain at injection site
- Joint pain
- Blurred vision
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Calcium Channel Blockers (Amlodipine, Diltiazem, Verapamil, Nifedipine, Felodipine, Nicardipine, Isradipine), oral hypoglycaemics, β-blockers, Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene)
|
Dosage adjustment of concurrent therapy may be necessary
|
|
Bromocriptine
|
May increase concentration
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity
|
Severe allergic reaction risk
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 2-8° C. Stable at room temperature for up to 14 days.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.