Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Rh-incompatible Pregnancy Routine antepartum prophylaxis Condition: Administer to Mother |
Dose: Intravenous or Intramuscular – 300 mcg (1500 IU) Note: Administer between weeks 28-30 of pregnancy |
|
Indication: Rh-incompatible Pregnancy Postpartum prophylaxis Condition: Newborn is Rh(D)-positive, or of unknown status |
Dose: Intravenous or Intramuscular – 300 mcg (1500 IU) Note: Administer within 72 hours of birth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Treatment of immune thrombocytopenic purpura (ITP) Age: Children |
Dose: Intravenous – 250 IU/kg (50 mcg/kg) Frequency: Once Note: Maximum dose 3000 mcg (15000 IU) |
Administration
- For IM use only
- Give within specified timeframe
Side Effect
- intravascular hemolysis
- clinically compromising anemia
- acute renal insufficiency
- and
- very rarely
- DIC and death
- nausea
- dizziness
- headache
- injection-site pain
- and malaise
- chills
- pyrexia/increased body temperature
- headache
- Mild hemolysis (manifested by an increase in bilirubin, a decrease in hemoglobin, or a decrease in haptoglobin) was also observed
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Live measles vaccine, live mumps vaccine, live rubella vaccine, live varicella vaccine
|
May interfere with the immune response; these vaccines should be given at least 3 wk before or 3 mth after the admin of the immunoglobulins
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
IgA deficiency with antibodies
|
Risk of severe reaction
|
|
History of anaphylaxis
|
Risk of life-threatening reaction
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Should be stored in cool and dry place.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.