Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute migraine attacks Age: Adult |
Dose: Oral – Initially, 6.25-12.5 mg Note: May repeat 2 hours later if needed. Maximum: 2 doses per 24 hours. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Migraine Age: Child less than 12 years |
Dose: Oral – Not established Note: Safety and efficacy not established |
|
Indication: Migraine Age: Child greater than 12 years |
Dose: Oral – 6.25-12.5 mg Frequency: at onset of headache; may repeat once after 2 hours Note: Not to exceed 25 mg/day; by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Not specified – 6.25 mg Frequency: once Note: Initially as a single dose. Maximum: 12.5 mg per 24 hours. |
Administration
- Take at first sign of migraine
- Can take with or without food
Side Effect
- Somnolence (1-5%)
- Dizziness (3-4%)
- Nausea (1-3%)
- Vomiting (2%)
- Dry mouth (1-2%)
- Headache (1-2%)
- Paresthesia (1-2%)
- Paresthesia (1%)
- Somnolence (More than 1%)
- Anxiety
- asthenia
- chills
- CNS stimulation
- fatigue
- hypesthesia
- tremor
- Pruitus
- rash
- Diaphoresis
- dysmenorrhea
- hyperglycemia
- increased thirst
- Abdominal cramp
- gastroenteritis
- Back pain
- myalgia
- neck pain
- rigid neck
- Increased CPK
- Bronchitis
- chest pain
- dyspnea
- pharyngitis
- rhinitis
- sinusitis
- Conjunctivitis
- tinnitis
- vertigo
- Serious cardiac events
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
SSRIs, Serotonin norepinephrine reuptake inhibitors
|
Increased risk of serotonin syndrome
|
|
Verapamil, Ketoconazole, Other potent CYP450 inhibitors
|
Increased plasma concentrations
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Cardiovascular Disease
|
Risk of heart complications
|
|
Uncontrolled Hypertension
|
Risk of blood pressure crisis
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30° C temperature in a dry place. Protected from light. Do not freeze. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.