Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Depression Age: Adult |
Dose: Oral – Initially, 75 mg Frequency: in divided doses Note: may gradually increase to 150-200 mg daily as necessary. Maximum: 300 mg/day. May give in divided doses or single dose at bedtime. |
|
Indication: Depression Age: Adult Condition: Maintenance dose |
Dose: Oral – 50-100 mg Frequency: once daily by mouth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Nocturnal enuresis Age: 6-7 years |
Dose: Oral – 25 mg Frequency: once daily Duration: Maximum treatment duration: 3 months Note: Doses are given just before bedtime |
|
Indication: Nocturnal enuresis Age: 8-11 years |
Dose: Oral – 25-50 mg Frequency: once daily Duration: Maximum treatment duration: 3 months Note: Doses are given just before bedtime |
Administration
- Can take with/without food
- Regular timing
Side Effect
- Orthostatic hypotension
- HTN
- tachycardia
- palpitation
- MI
- arrhythmias
- heart block
- ECG changes
- precipitation of CHF
- stroke
- confusional states (esp in elderly) w/ hallucinations
- disorientation
- delusions
- anxiety
- restlessness
- agitation
- insomnia and nightmares
- hypomania
- exacerbation of psychosis
- numbness
- tingling
- paraesthesias of extremities
- incoordination
- ataxia
- tremors
- peripheral neuropathy
- extrapyramidal symptoms
- seizures
- altered EEG patterns
- tinnitus
- dry mouth
- rarely
- associated SL adenitis
- blurred vision
- accommodation disturbances
- mydriasis
- constipation
- paralytic ileus
- urinary retention
- delayed micturition
- dilated urinary tract
- skin rash
- petechiae
- urticaria
- itching
- photosensitization
- oedema
- drug fever
- bone marrow depression
- agranulocytosis
- eosinophilia
- purpura
- thrombocytopenia
- nausea and vomiting
- anorexia
- epigastric distress
- diarrhoea
- peculiar taste
- stomatitis
- abdominal cramps
- black tongue
- gynaecomastia (male)
- breast enlargement and galactorrhea (female)
- increased/decreased libido
- impotence
- testicular swelling
- increased/decreased blood sugar levels
- inappropriate antidiuretic hormone secretion syndrome
- jaundice
- altered liver function
- weight gain/loss
- perspiration
- flushing
- urinary frequency
- drowsiness
- dizziness
- weakness and fatigue
- headache
- parotid swelling
- alopecia
- proneness to falling
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Quinidine, Cimetidine, SSRIs, Propafenone, Flecainide
|
Increased plasma levels and effects
|
|
Barbiturates, Phenytoin
|
Reduced plasma levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Heart Block Or Cardiac Arrhythmias
|
Can worsen heart rhythm
|
|
Recent MI
|
Can stress heart
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.