Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension |
Dose: Tablet – 4 mg/5 mg Frequency: once daily Note: Taken by mouth with or without food. Adjust dose according to blood pressure goals; wait 7-14 days between titration steps. Not to exceed 14 mg/10 mg once daily. |
|
Indication: Hypertension Condition: Hepatic impairment |
Dose: Tablet – Dosage not specified Note: There are no data to guide dosing recommendations. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment CrCl less than 30 mL/min |
Dose: Not recommended Note: Renal Impairment CrCl less than 30 mL/min: Not recommended |
|
Condition: Renal Impairment CrCl 30-80 mL/min (mild or moderate renal impairment) |
Dose: 7/5 mg Note: Do not exceed 7/5 mg |
Administration
- Take on empty stomach
- Take at the same time each day
Side Effect
- Peripheral edema (7.2%)
- Cough (3.2%)
- Headache (2.5%)
- Dizziness (2.5%)
- Dermatologic Rash
- Digestive Nausea
- diarrhea
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Antihypertensive (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, Propranolol, Metoprolol, Atenolol, Carvedilol, Bisoprolol, Nadolol, Amlodipine, Diltiazem, Verapamil, Nifedipine, Nicardipine, Hydrochlorothiazide, Chlorthalidone, Indapamide, Furosemide, Bumetanide, Torsemide, Spironolactone, Amiloride, Triamterene, Prazosin, Doxazosin, Terazosin, Clonidine, Methyldopa, Hydralazine, Minoxidil), diuretics, vasodilators
|
Increased hypotensive effects
|
|
Lithium
|
May increase serum levels and toxicity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Idiopathic angioedema
|
Risk of severe swelling
|
|
Severe hypotension
|
Can worsen low blood pressure
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a dry place below 25⁰C. Keep the container tightly closed and protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.