Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Absence seizures Age: Adult |
Dose: Oral – Initially, 500 mg Frequency: daily Note: May increase in steps of 250 mg at intervals of 4-7 days. Usual dose: 1-1.5 g daily. Maximum: Up to 2 g in some patients. Strict supervision is recommended if dose greater than 1.5 g daily. Optimum plasma concentration: 40-100 mg/L (300-700 micromol/L). |
|
Indication: Absence seizures Age: Adult Condition: Hepatic Impairment |
Dose: Oral Note: Monitor closely |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Children |
Dose: Oral – 50 mg/kg/day Frequency: every 6 to 8 hours Note: by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Not specified Note: Monitor closely |
Administration
- Take with food
- Take with water
Side Effect
- Dizziness
- Headache
- Somnolence
- Anorexia
- Diarrhea
- GI upset
- Nausea
- Vomiting
- Ataxia
- confusion
- drowsiness
- sleep disturbance
- Gum hypertrophy
- hicCough
- swelling of tongue
- Blood dyscrasias including aplastic anemia
- Allergic reaction
- Urticaria
- Pruritic erythematous rashes
- Blurred vision
- myopia
- Psychosis
- Seizure
- Suicidal thoughts and behavior
- Stevens-Johnson syndrome
- Systemic lupus erythematosus
- Hirsutism
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Isoniazid
|
May increase serum concentration, leading to toxicity
|
|
Antipsychotics (Haloperidol, Risperidone, Quetiapine, Olanzapine, Clozapine, Aripiprazole), Antidepressants (Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Venlafaxine, Duloxetine), MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide), Mefloquine
|
May antagonise anticonvulsant effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.