Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: ICU Sedation Age: Adult |
Dose: Intravenous Loading Dose – 1 microgram/kilogram Duration: over 10 minutes Note: Titrate less frequently than every 30 minutes to prevent hypotension |
|
Indication: ICU Sedation Age: Adult |
Dose: Intravenous Maintenance Infusion – 0.2-1.4 microgram/kilogram/hour Note: Titrate less frequently than every 30 minutes to prevent hypotension |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy – not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment (SL, BUC) all severities |
Dose: Not specified Note: No dosage adjustment necessary |
Administration
- For IV use only
- Dilute in normal saline
Side Effect
- Hypotension (28%)
- AFib
- Anemia
- Bradycardia
- Fever
- Pleural effusion
- Leukocytosis
- Pulmonary edema
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Anaesthetics, sedatives, hypnotics, opiate agonists, other vasodilators, drugs with negative chronotropic effects (e.g. cardiac glycosides)
|
Enhanced pharmacologic effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Heart Block (2nd/3rd degree)
|
Risk of cardiac complications
|
|
Uncontrolled Hypotension
|
Risk of dangerous blood pressure drop
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.