Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Primary hyperlipidemia, including heterozygous familial hypercholesterolemia Age: Adults |
Dose: Tablet – 180 mg Frequency: once daily Note: Indicated as an adjunct to diet, in combination with other low-density lipoprotein cholesterol lowering therapies, or alone when concomitant low-density lipoprotein cholesterol lowering therapy is not possible. |
|
Indication: Cardiovascular Risk Reduction Age: Adults Condition: Unable to take recommended statin therapy with established cardiovascular disease, or a high risk for a cardiovascular disease event but without established cardiovascular disease |
Dose: Tablet – 180 mg Frequency: once daily Note: Indicated to reduce risk of myocardial infarction and coronary revascularization. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Not applicable – No approved pediatric dosage available Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Mild or moderate (estimated glomerular filtration rate greater than or equal to 30 mL/min/1.73 m2) |
Dose: Not specified Note: No dosage adjustment required |
|
Condition: Renal impairment Severe (estimated glomerular filtration rate less than 30 mL/min/1.73 m2) |
Dose: Not specified Note: Data are limited |
Administration
- Take with or without food
- Take at the same time each day
Side Effect
- Upper respiratory tract infection (URTI) (4.5%)
- Muscle spasms (3.6%)
- Hyperuricemia (3.5%)
- Back pain (3.3%)
- Abdominal pain or discomfort (3.1%)
- Bronchitis (3%)
- Pain in extremity (3%)
- Anemia (2.8%)
- Elevated liver enzymes (2.1%)
- Gout (1.5%)
- Benign prostatic hyperplasia (1.3%)
- Atrial fibrillation (1.7%)
- Tendon rupture (0.5%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Simvastatin
|
Avoid doses >20 mg
|
|
Pravastatin
|
Avoid doses >40 mg
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30oC temperature, protected from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.