Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Eradication of H. pylori to reduce risk of duodenal ulcer recurrence |
Dose: Oral Capsule/Tablet – Lansoprazole 30 mg, amoxicillin 1 g (2 x 500 mg capsules), and clarithromycin 500 mg Frequency: twice daily (morning and evening) Duration: 10 or 14 days Note: Each dose of this combination therapy contains 4 pills: 1 capsule lansoprazole 30 mg, 2 capsules amoxicillin 500 mg, and 1 tablet clarithromycin 500 mg administered together by mouth. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Severe renal impairment (Creatinine Clearance less than 30 mL/min) |
Dose: Not specified Note: Do not use |
Administration
- Take with food
- Follow exact schedule
Side Effect
- GI effects, general (13%)
- Headache (6%)
- Rash (children 3%)
- Abdominal pain (adults 2%
- children 3%)
- Abnormal taste (adults 3-7%)
- Diarrhea (3-6%)
- Dyspepsia (2%)
- Heartburn (adults 2%)
- GI intolerance (oral-dose related)
- Nausea (adults 3-6%)
- Vomiting (adults 1%
- children 6%)
- Decreased WBC
- elevated BUN (4%)
- elevated PT (1%)
- Fatigue (Less than 3%)
- Headache (2.5-4.7%)
- Abdominal pain (1.8%)
- Diarrhea (8%)
- Nausea (3.7%)
- QT prolongation
- Anxiety
- dizziness
- hallucinations
- manic behavior
- neuromuscular blockade
- psychosis
- seizures
- Anorexia
- glossitis
- pancreatitis
- AST increased
- bilirubin increased
- elevated LFTs
- hepatic dysfunction
- hepatitis
- increased alkaline phosphate
- jaundice
- Hypoglycemia
- leukopenia
- neutropenia
- thrombocytopenia
- Increased serum creatinineeatinine
- Dyspnea
- Anaphylaxis
- C Diff colitis
- Stevens-Johnson syndrome
- Headache
- Rash
- Diarrhea
- nausea
- vomiting
- Anemia
- AST/ALT elevation
- Acute exanthematous pustulosis
- Exfoliative dermatitis
- Seizure
- Insomnia
- Hemorrhagic colitis
- Toxic epidermal necrolysis
- Urticaria
- Stevens-Johnson syndrome
- Anaphylaxis
- Candidiasis (mucocutaneous)
- pseudomembranous colitis
- serum sickness
- Torsade de pointes (rare)
- Allergic reactions
- urticaria & skin eruptions
- leukocytoclastic vasculitis
- toxic epidermal necrolysis
- pruritus
- rash
- Transient CNS effects psychosis
- anxiety
- behavioral changes
- confusional states
- depersonalization
- disorientation
- hallucinations
- insomnia
- nightmares
- tinnitus
- tremor
- and vertigo
- Hepatic failure
- Stomatitis
- Acute renal failure
- Reversible hearing loss (hypoacusis)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Oral Contraceptives
|
May reduce efficacy (Amoxicillin component)
|
|
Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban)
|
May increase effect (Amoxicillin component)
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Cholestatic Jaundice History
|
Risk of liver injury
|
|
Previous Clarithromycin-Related Hepatic Dysfunction
|
Risk of liver damage
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.