Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Osteoarthritis Age: Adult |
Dose: Oral – 1 g Frequency: once daily initially Note: maintenance: 1-2 g/day by mouth in single daily dose or divided every 12 hours; not to exceed 2 g/day |
|
Indication: Rheumatoid Arthritis Age: Adult |
Dose: Oral – 1 g Frequency: once daily initially Note: maintenance: 1-2 g/day by mouth in single daily dose or divided every 12 hours; not to exceed 2 g/day |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Dose: Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Creatinine Clearance 30-49 ml/min |
Dose: Dosage Recommendation – 750 mg Frequency: once daily Note: Maximum initial dose: 750 mg once daily. Increase if needed to a maximum dose of 1.5 g daily. |
|
Condition: Creatinine Clearance less than 30 ml/min |
Dose: Dosage Recommendation – 500 mg Frequency: once daily Note: Maximum initial dose: 500 mg once daily. Increase if needed to a maximum dose of 1 g daily. |
Administration
- Should be taken with food
- Take at regular intervals
Side Effect
- Diarrhea (14%)
- Dyspepsia (13%)
- Abdominal pain (12%)
- Constipation (3-9%)
- Dizziness (3-9%)
- Edema (3-9%)
- Flatulence (3-9%)
- Headache (3-9%)
- Nausea (3-9%)
- Positive stool guaiac (3-9%)
- Pruritus (3-9%)
- Rash (3-9%)
- Tinnitus (3-9%)
- Dry mouth (1-3%)
- Fatigue (1-3%)
- Gastritis (1-3%)
- Increased sweating (1-3%)
- Insomnia (1-3%)
- Nervousness (1-3%)
- Somnolence (1-3%)
- Stomatitis (1-3%)
- Vomiting (1-3%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Hypotensive agents
|
Antihypertensive effects may be reduced
|
|
Ciclosporin
|
May increase levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Aspirin Allergy
|
Risk of severe allergic reaction
|
|
Severe Renal Impairment
|
Risk of kidney complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 25°C; excursions permitted to 15-30°C in well-closed container; dispense in light-resistant container.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.