Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Menopausal Vasomotor Symptoms, Atrophic Vaginitis/Kraurosis Vulvae |
Dose: Tablet – 0.3 mg Frequency: by mouth once daily in either continuous daily regimen or cyclic regimen (25 days on, 5 days off) Note: Adjusted as needed; use lowest dose that control symptoms; may be given daily if medical assessment warrants it |
|
Indication: Female Hypogonadism |
Dose: Tablet – 0.3-0.625 mg Frequency: by mouth once daily in cyclic regimen (3 weeks on, 1 week off) Note: May be titrated every 6-12 months; adjusted as needed; add progestin treatment should be added to maintain bone mineral density once skeletal maturity achieved |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Not applicable – No approved pediatric dosage available Note: No approved pediatric dosage available |
Administration
- Can be taken with or without food
- Take at same time daily
Side Effect
- Abdominal pain (15-17%)
- Back pain (13-14%)
- Breast enlargement
- Breast tenderness (7-12%)
- Headache (26-32%)
- Arthralgia (7-14%)
- Pharyngitis (10-12%)
- Sinusitis (6-11%)
- Diarrhea (6-7%)
- Depression (5-8%)
- Dizziness (4-6%)
- Nervousness (2-5%)
- Flatulence (6-7%)
- Vaginitis (5-7%)
- Leukorrhea (4-7%)
- Leg cramps (3-7%)
- Increased cough (4-7%)
- Pruritus (4-5%)
- Amenorrhea
- Breakthrough bleeding
- Corneal curvation change
- Melasma
- Spotting
- Vaginal moniliasis
- Weight changes
- Unopposed replacement therapy in postmenopausal women associated with increased risk of endometrial and breast cancer
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Rifampicin, Barbiturates
|
Increase rate of metabolism
|
|
Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban)
|
May reduce the efficacy
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Liver Impairment
|
Can cause liver toxicity
|
|
Breast Carcinoma
|
Can stimulate cancer growth
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool (below 30°C) and dry place, protected from light and moisture.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.