Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral – Initially, 12.5 mg, may increase to 25-50 mg Frequency: once daily Note: titrate as necessary either alone or with other antihypertensives |
|
Indication: Hypertension Age: Elderly |
Dose: Oral – 12.5-25 mg Frequency: once daily Note: titrate as necessary in increments of 12.5 mg |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: less than 6 month |
Dose: Oral – 1-3 mg/kg/day Frequency: in 1-2 divided doses Note: Maximum: 37.5 mg daily |
|
Indication: Hypertension Age: 6 month to 2 year |
Dose: Oral – 1-2 mg/kg/day Frequency: in 1-2 divided doses Note: Maximum: 37.5 mg daily |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Creatinine Clearance less than 10 mL/min |
Dose: Not specified Note: Avoid use |
|
Condition: Renal impairment Creatinine Clearance greater than 10 mL/min |
Dose: Not specified Note: Dose adjustment not necessary; not effective with Creatinine Clearance less than 30 mL/min unless used in combination with loop diuretic |
Administration
- Take with food
- Same time daily
Side Effect
- Electrolyte disturbances
- weakness
- hypotension
- pancreatitis
- jaundice
- diarrhoea
- vomiting
- sialadenitis
- cramping
- constipation
- gastric irritation
- nausea
- anorexia
- aplastic anaemia
- agranulocytosis
- leukopenia
- haemolytic anaemia
- thrombocytopenia
- anaphylactic reactions
- necrotising angiitis
- resp distress
- photosensitivity
- fever
- urticaria
- rash
- purpura
- hyperglycaemia
- glycosuria
- hyperuricaemia
- muscle spasm
- vertigo
- paraesthesias
- dizziness
- headache
- restlessness
- renal failure
- renal dysfunction
- interstitial nephritis
- erythema multiforme
- exfoliative dermatitis
- alopecia
- transient blurred vision
- xanthopsia
- impotence
- Hypersensitivity reactions
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Lithium
|
Increases toxicity
|
|
Barbiturates, Narcotics
|
May potentiate orthostatic hypotension
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Anuria
|
Can worsen kidney function
|
|
Severe Renal Impairment
|
Can cause electrolyte imbalance
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-30°C. Protect from light, moisture and freezing.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.